Baclofen treatment in chronic schizophrenia: a clinical trial.
Baclofen treatment in chronic schizophrenia: a clinical trial.
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巴氯芬治疗慢性精神分裂症：一项临床试验。
DOI：
10.1176/ajp.134.3.318
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发表时间：
1977
期刊：
影响因子：
--
通讯作者：
R. Wyatt
中科院分区：
文献类型：
--
作者：
L. Bigelow;H. Nasrallah;J. Carman;J. Gillin;R. Wyatt
9名年轻（平均年龄25岁）慢性精神分裂症患者参加了巴氯芬疗效的双盲交叉研究。s未能对常规治疗措施作出充分反应，不能允许他们在医院环境外生活。给予60或80毫克/天的巴氯芬或安慰剂。每个S接受临床最佳剂量的抗精神病药物，并在研究期间继续服用。由护理人员使用27项评定量表监测临床状态，每日2次，采用配对t检验分析治疗效果。两组均无明显临床改善。此外，负责Ss护理的临床医生在任何时候都不认为需要减少神经安定药的剂量。结果不支持PK Frederiksen（1975）的发现，他在一项公开研究中将巴氯芬添加到13名慢性精神分裂症患者的抗精神病药物方案中，并报告大多数患者得到改善。（PsycINFO数据库记录(c) 2016 APA，版权所有）
Nine young (mean age 25 yrs) chronic schizophrenic patients participated in a double-blind crossover study of the effects of baclofen. Ss had failed to respond sufficiently to conventional therapeutic measures to permit them to live outside a hospital environment. 60 or 80 mg/day of baclofen or placebo were administered. Each S was receiving a clinically optimum dose of neuroleptic drug, which was continued during the study. Clinical status was monitored twice daily by a nursing staff using a 27-item rating scale, and effects of treatment were analyzed using a paired t test. None of the Ss showed major clinical improvement. In addition, clinicians in charge of Ss' care did not at any time feel that any dosage reduction of neuroleptic was indicated. Results do not support the findings of PK Frederiksen (1975) who added baclofen to the neuroleptic regimen of 13 chronic schizophrenics in an open study and reported that most patients improved.(PsycINFO Database Record (c) 2016 APA, all rights reserved)