The Nucleus's Revolving Door
The Nucleus's Revolving Door
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核心的旋转门
作者：
E. Pennisi
过去两年的工作表明，细胞已经进化出一个高度复杂的系统，涉及结构相关的许多不同蛋白质之间的复杂分工，用于将蛋白质和mRNA等大分子运送到细胞核内外。最近的研究还表明，一种名为Ran的小蛋白质充当调度器，协调运输方向，并将各种核运输途径与细胞生死中的关键事件联系起来。由于细胞分裂和蛋白质合成等关键过程取决于必须在正确的时间进入或离开细胞核的分子，这些新发现引起越来越多的研究人员注意到核运输在细胞生命中发挥的关键作用。
Work done over the past 2 years shows that cells have evolved a highly complex system, involving an intricate division of labor among a host of different proteins that are structurally related, for transporting large molecules such as proteins and mRNAs into and out of the nucleus. Recent work also indicates that a small protein called Ran acts as the dispatcher, coordinating the direction of transport and linking the various nuclear transport pathways with critical events in the life and death of the cell. Because critical processes such as cell division and protein synthesis depend on molecules that have to be carried into or out of the nucleus at exactly the right time, these new findings are causing more and more researchers to take notice of the pivotal role nuclear transport plays in the life of the cell.