EphB receptors regulate stem/progenitor cell proliferation, migration, and polarity during hippocampal neurogenesis
EphB receptors regulate stem/progenitor cell proliferation, migration, and polarity during hippocampal neurogenesis
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DOI：
10.1523/jneurosci.4158-07.2007
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发表时间：
2007-12-05
影响因子：
5.3
通讯作者：
Henkemeyer, Mark
中科院分区：
文献类型：
--
作者：
Chumley, Michael J.;Catchpole, Timothy;Henkemeyer, Mark
成人大脑维持着两个神经发生区域，新神经元从这两个区域诞生，迁移到合适的位置，并融入中枢神经系统的回路。其中之一是海马齿状回的颗粒下区，由于该区域在学习和记忆中的作用，因此引起了人们的主要兴趣。我们发现，缺乏EphB1的小鼠，更深入地说，EphB1和EphB2，在海马区的神经前体细胞明显较少。此外，在缺乏EphB1受体或其同源ePhin-B3配体的动物中，神经发生的其他方面，如极性、细胞定位和增殖都会受到干扰。我们的数据有力地表明，EphB1和ephin-B3协同调节海马区神经前体细胞的增殖和迁移，应该被添加到调控新神经元的产生和整合的候选靶分子名单中，作为治疗神经退行性疾病或脑损伤的方法。
The adult brain maintains two regions of neurogenesis from which new neurons are born, migrate to their appropriate location, and become incorporated into the circuitry of the CNS. One of these, the subgranular zone of the hippocampal dentate gyrus, is of primary interest because of the role of this region in learning and memory. We show that mice lacking EphB1, and more profoundly EphB1 and EphB2, have significantly fewer neural progenitors in the hippocampus. Furthermore, other aspects of neurogenesis, such as polarity, cell positioning, and proliferation are disrupted in animals lacking the EphB1 receptor or its cognate ephrin-B3 ligand. Our data strongly suggest that EphB1 and ephrin-B3 cooperatively regulate the proliferation and migration of neural progenitors in the hippocampus and should be added to a short list of candidate target molecules for modulating the production and integration of new neurons as a treatment for neurodegenerative diseases or brain injury.