Asymmetric Aldol Reaction of Chloral Catalyzed by Diarylprolinol
Asymmetric Aldol Reaction of Chloral Catalyzed by Diarylprolinol
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二芳基脯氨醇催化氯醛不对称羟醛反应
DOI：
10.1002/cctc.201500282
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发表时间：
2015
期刊：
影响因子：
4.5
通讯作者：
S. Umemiya
中科院分区：
文献类型：
--
作者：
Y. Hayashi;S. Watanabe;Y. Yasui;S. Umemiya
在三氟甲基取代的二芳基脯氨醇催化下，水合氯醛与醛亲核试剂发生不对称交叉羟醛反应，以良好的收率和优异的对映选择性生成γ-三氯-β-羟基醛。所得醛产物被转化为手性α-叠氮基、α-(4-甲基)苯氧基和α-氟酯，且不损失非对映选择性或对映选择性。
The asymmetric cross‐aldol reaction of chloral hydrate with aldehyde pronucleophiles catalyzed by a trifluoromethyl‐substituted diarylprolinol was accomplished to afford γ‐trichloro‐β‐hydroxy aldehydes in good yields with excellent enantioselectivities. The resulting aldehyde products were converted into chiral α‐azido, α‐(4‐methyl)phenoxy, and α‐fluoro esters without a loss in the diastereo‐ or enantioselectivities.