Toxic Effect of Visible Light on Drosophila Life Span Depending on Diet Protein Content.
Toxic Effect of Visible Light on Drosophila Life Span Depending on Diet Protein Content.
复制标题
可见光对果蝇寿命的毒性影响取决于饮食蛋白质含量。
DOI：
10.1093/gerona/gly042
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Xiao Qing
中科院分区：
文献类型：
--
作者：
Shen Jie;Zhu Xiang;Gu Yitian;Zhang Chiqian;Huang Jiahong;Xiao Qing
我们研究了可见光对雌雄果蝇寿命的毒性效应。紫外线对生物体的毒性作用是众所周知的。然而，用可见光照明的效果仍然不清楚。在这里，我们发现可见光可能对果蝇存活有毒性，这取决于食物中的蛋白质含量。此外，进一步的分析表明，光和性别之间的显着相互作用，并表明，强光缩短寿命，造成相反方向的变化，死亡率参数在女性与男性。我们的研究结果表明，光老化可能是一种普遍现象，并支持衰老干预中的性拮抗多效性理论。结果警告说，暴露于可见光可能对寿命有害，并表明确定潜在的机制将有助于更好地理解衰老干预。
We investigated the toxic effect of visible light onDrosophilalife span in both sexes. The toxic effect of ultraviolet light on organisms is well known. However, the effects of illumination with visible light remain unclear. Here, we found that visible light could be toxic toDrosophilasurvival, depending on the protein content in diet. In addition, further analysis revealed significant interaction between light and sex and showed that strong light shortened life span by causing opposite direction changes in mortality rate parameters in females versus males. Our findings suggest that photoaging may be a general phenomenon and support the theory of sexual antagonistic pleiotropy in aging intervention. The results caution that exposure to visible light could be hazardous to life span and suggest that identification of the underlying mechanism would allow better understanding of aging intervention.