Mechanisms linking obesity with cardiovascular disease
Mechanisms linking obesity with cardiovascular disease
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DOI：
10.1038/nature05487
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发表时间：
2006-12-14
期刊：
影响因子：
64.8
通讯作者：
De Block, Christophe E.
中科院分区：
文献类型：
--
作者：
Van Gaal, Luc F.;Mertens, Ilse L.;De Block, Christophe E.
肥胖会增加心血管疾病和过早死亡的风险。脂肪组织释放大量的生物活性介质，不仅影响体重稳态，而且影响胰岛素抵抗-2型糖尿病的核心特征-以及脂质、血压、凝血、纤维蛋白溶解和炎症的改变，导致内皮功能障碍和动脉粥样硬化。我们现在开始了解肥胖对心血管健康的不利影响的潜在机制以及吸烟和血脂异常增加、体力活动减弱的方式。
Obesity increases the risk of cardiovascular disease and premature death. Adipose tissue releases a large number of bioactive mediators that influence not only body weight homeostasis but also insulin resistance - the core feature of type 2 diabetes - as well as alterations in lipids, blood pressure, coagulation, fibrinolysis and inflammation, leading to endothelial dysfunction and atherosclerosis. We are now beginning to understand the underlying mechanisms as well as the ways in which smoking and dyslipidaemia increase, and physical activity attenuates, the adverse effects of obesity on cardiovascular health.