Topography of projections to the frontal lobe from the macaque frontal eye fields.
Topography of projections to the frontal lobe from the macaque frontal eye fields.
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从猕猴额眼区域投射到额叶的地形图。
DOI：
10.1002/cne.903300209
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Goldberg,ME
中科院分区：
文献类型：
--
作者：
Stanton,GB;Bruce,CJ;Goldberg,ME
从额叶眼野（FEF）同侧额叶的传出神经进行了研究氚示踪剂（亮氨酸，脯氨酸，岩藻糖）在7只猕猴，以前被用来描述皮层下连接的放射自显影。在四个案例中，示踪剂注射部位被确认为低阈值的电诱发扫视眼球运动。根据注射部位特征性的大或小扫视，将例患者分为lFEF或sFEF病例。FEF的投射终止于五个额叶区域：（1）背内侧凸部FD区;（2）FC区;（3）FEF区;（4）FEF区。（3）沿主沟壁的FD和FDΔ沿着;（4）FCBm区，位于弓状沟后壁的深部，沟距下方;（5）下外侧皮质区，位于弓状沟前壁的凸面和外侧2/3处。sFEF病例的投射倾向于局限于背内侧FD和FC的内侧部分以及主沟和下外侧凸的外侧壁。lFEF和sFEF均未投射到SMA或扣带回周围皮质。这些区域的标记仅在示踪剂扩散到非FEF区域的情况下发现。FEF投射终止于直径约500-600 μm的柱状斑块。标记的轴突和终端被认为是在所有的皮质层，无论在额叶的位置。
Efferents from the frontal eye fields (FEF) to the ipsilateral frontal lobe were studied by autoradiography of tritiated tracers (leucine, proline, and fucose) in seven macaque monkeys that were used previously to describe subcortical connections. In four of the cases, tracer injection sites were confirmed by low thresholds for the electrical elicitation of saccadic eye movements. Cases were grouped as lFEF or sFEF cases according to large or small saccades that were characteristic of the injection site.Projections from the FEF terminated in five frontal regions: (1) area FD on the dorsomedial convexity; (2) area FC (containing SEF) medial to the upper limb of the arcuate sulcus; (3) areas FD and FDΔ along the walls of the principal sulcus; (4) area FCBm on the deep, posterior wall of the arcuate sulcus inferior to the sulcal spur; and (5) the inferolateral cortex (area FDi) on the convexity and lateral two thirds of the anterior wall of the arcuate sulcus. Projections in sFEF cases tended to be confined to medial parts of dorsomedial FD and FC and the lateral wall of the principal sulcus and inferolateral convexity. Neither lFEF nor sFEF appeared to project to the SMA or pericingulate cortex. Label in these areas was found only in the cases in which tracer spread into non‐FEF areas.FEF projections terminated in column‐like patches of about 500–600 μm in diameter. Labeled axons and terminals were seen in all cortical layers regardless of location in the frontal lobe.