Regulation of Mitochondrial Structure and Dynamics by the Cytoskeleton and Mechanical Factors.
Regulation of Mitochondrial Structure and Dynamics by the Cytoskeleton and Mechanical Factors.
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DOI：
10.3390/ijms18081812
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发表时间：
2017-08-21
影响因子：
5.6
通讯作者：
Suki B
中科院分区：
文献类型：
--
作者：
Bartolák-Suki E;Imsirovic J;Nishibori Y;Krishnan R;Suki B
线粒体以ATP的形式为细胞提供能量，引导细胞凋亡，并有助于钙缓冲和活性氧的产生。为了支持这些不同的功能，线粒体形成了一个广泛的网络与较小的集群，能够移动沿着微管的辅助下马达蛋白。线粒体也与肌动蛋白网络相关，肌动蛋白网络参与细胞对各种机械因素的反应。在这篇综述中，我们讨论了线粒体的结构和功能的细胞骨架和各种机械因素影响细胞功能。我们首先总结了线粒体的形态特征，重点是分裂和融合以及网络特性如何支配功能。然后，我们审查线粒体和细胞骨架结构之间的关系，包括机械相互作用。我们还讨论了拉伸及其动态模式如何影响线粒体的结构和功能。最后，我们目前的初步数据，细胞外基质硬度如何影响线粒体形态和ATP的产生。最后，我们讨论了线粒体在机械生物学中可能发挥的更普遍的作用，以及线粒体的机械敏感性如何可能有助于几种疾病和衰老的发展。
Mitochondria supply cells with energy in the form of ATP, guide apoptosis, and contribute to calcium buffering and reactive oxygen species production. To support these diverse functions, mitochondria form an extensive network with smaller clusters that are able to move along microtubules aided by motor proteins. Mitochondria are also associated with the actin network, which is involved in cellular responses to various mechanical factors. In this review, we discuss mitochondrial structure and function in relation to the cytoskeleton and various mechanical factors influencing cell functions. We first summarize the morphological features of mitochondria with an emphasis on fission and fusion as well as how network properties govern function. We then review the relationship between the mitochondria and the cytoskeletal structures, including mechanical interactions. We also discuss how stretch and its dynamic pattern affect mitochondrial structure and function. Finally, we present preliminary data on how extracellular matrix stiffness influences mitochondrial morphology and ATP generation. We conclude by discussing the more general role that mitochondria may play in mechanobiology and how the mechanosensitivity of mitochondria may contribute to the development of several diseases and aging.
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DOI：
10.1073/pnas.0307156101
发表时间：
2004-03-30
影响因子：
11.1
作者：
Aon, MA;Cortassa, S;O'Rourke, B
通讯作者：
O'Rourke, B
DOI：
10.1073/pnas.1019188108
发表时间：
2011-06-07
影响因子：
11.1
作者：
Araujo, Ascanio D.;Majumdar, Arnab;Suki, Bela
通讯作者：
Suki, Bela
影响因子：
41.2
作者：
Bartolak-Suki, Erzsebet;Imsirovic, Jasmin;Suki, Bela
通讯作者：
Suki, Bela
影响因子：
4.8
作者：
Carré, M;André, N;Braguer, D
通讯作者：
Braguer, D
影响因子：
3.4
作者：
EHRENBERG, B;MONTANA, V;LOEW, LM
通讯作者：
LOEW, LM