Exercise training alters an anoxia-induced, glibenclamide-sensitive current in rat ventricular cardiocytes.
Exercise training alters an anoxia-induced, glibenclamide-sensitive current in rat ventricular cardiocytes.
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运动训练改变大鼠心室心肌细胞中缺氧诱导的格列本脲敏感电流。
DOI：
10.1152/japplphysiol.00513.2001
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Moore,RussellL
中科院分区：
文献类型：
--
作者：
Jew,KorinneN;Moore,RussellL
The effect of training on properties of a sarcolemmal ATP-sensitive K+current (IKATP) was examined in left ventricular cardiocytes isolated from sedentary (Sed) and trained (Tr) female Sprague-Dawley rats. Whole cell patch-clamp techniques were used to characterizeIKATP, an anoxia-inducible, glibencamide-sensitive current. An anoxic condition was induced by superfusing cells with a buffer that was equilibrated with 100% N2, maintained under a layer of argon, and that contained 2-deoxy-d-glucose. Over a 1-h period of anoxia, 59% of Tr cells and 85% Sed cells expressedIKATP. In those cells that did expressIKATP, the time to expression of the current during the anoxic period occurred significantly later in cells from the Tr group compared with the Sed. PeakIKATPdensity was significantly lower in the Tr cells compared with the Sed cells. These results indicate that the onset and magnitude ofIKATPwere altered by training. These alterations inIKATPmay be reflective of processes that contribute to training-induced cardioprotection against ischemia-reperfusion damage.
