Update on Lupus Nephritis
Update on Lupus Nephritis
复制标题
狼疮性肾炎的最新进展
DOI：
10.2215/cjn.05780616
复制
发表时间：
2017-05-01
影响因子：
9.8
通讯作者：
Rovin, Brad H.
中科院分区：
文献类型：
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作者：
Almaani, Salem;Meara, Alexa;Rovin, Brad H.
SLE 是一种慢性炎症性疾病，约 50% 的患者会影响肾脏。狼疮性肾炎是 SLE 总体发病率和死亡率的主要危险因素，尽管采用有效的抗炎和免疫抑制治疗，仍有太多患者以 CKD 或 ESRD 告终。这篇综述重点介绍了我们对疾病流行病学、遗传学、发病机制和治疗的最新认识，旨在建立针对患者的狼疮肾炎管理框架，该框架旨在维持狼疮患者的长期肾功能。
SLE is a chronic inflammatory disease that affects the kidneys in about 50% of patients. Lupus nephritis is a major risk factor for overall morbidity and mortality in SLE, and despite potent anti-inflammatory and immunosuppressive therapies still ends in CKD or ESRD for too many patients. This review highlights recent updates in our understanding of disease epidemiology, genetics, pathogenesis, and treatment in an effort to establish a framework for lupus nephritis management that is patient-specific and oriented toward maintaining long-term kidney function in patients with lupus.