Neurobiology of social behavior abnormalities in autism and Williams syndrome.
Neurobiology of social behavior abnormalities in autism and Williams syndrome.
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DOI：
10.1038/nn.4276
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发表时间：
2016-04-26
影响因子：
25
通讯作者：
Feng G
中科院分区：
文献类型：
--
作者：
Barak B;Feng G
社会行为是由多个脑区和神经回路介导的基本行为，对动物和人类的生存和发展至关重要。两种具有显著社会行为异常的神经精神障碍是自闭症谱系障碍（ASD），其主要特征是社交能力减退，以及威廉姆斯综合征（WS），其受试者表现出过度社交。在这里，我们回顾了ASD和WS的社会行为的独特属性，并讨论了在这些疾病的背景下，社会行为的主要理论。最后，我们讨论了需要进一步探索的研究问题，以提高我们对社会行为异常的理解。
Social behavior is a basic behavior mediated by multiple brain regions and neural circuits, and is crucial for the survival and development of animals and humans. Two neuropsychiatric disorders that have prominent social behavior abnormalities are autism spectrum disorders (ASD), which is characterized mainly by hyposociability, and Williams syndrome (WS), whose subjects exhibit hypersociability. Here, we review the unique properties of social behavior in ASD and WS, and discuss the major theories in social behavior in the context of these disorders. We conclude with a discussion of the research questions needing further exploration to enhance our understanding of social behavior abnormalities.