Effects of castration and androgen treatment on androgen-receptor levels in rat skeletal muscles
Effects of castration and androgen treatment on androgen-receptor levels in rat skeletal muscles
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DOI：
10.1152/jappl.1999.87.6.2016
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发表时间：
1999-12-01
影响因子：
3.3
通讯作者：
George, FW
中科院分区：
文献类型：
--
作者：
Antonio, J;Wilson, JD;George, FW
本实验观察了去势和双氢睾酮（DHT）处理对三组成年雄性大鼠骨骼肌雄激素受体（AR）水平的影响：（1）正常大鼠;（2）16周龄去势大鼠; 17.所有动物在18周龄时处死。去势组肛提肌和球海绵体肌重量显著降低（P < 0.05）。给去势大鼠灌服双氢睾酮后，肛提肌和球海绵体肌重量增加（P < 0.05）。去势使球海绵体肌中AR水平显著下调（P < 0.05），但对肛提肌中AR水平无显著影响。给去势组施用DHT可上调球海绵体肌和提肛肌中的AR水平。跖肌在任何处理下均无显著变化（P > 0.05）。这些结果表明，去势和雄激素替代的影响差异影响骨骼肌质量和AR水平。
The effects of castration and dihydrotestosterone (DHT) treatment on levels of skeletal muscle androgen receptor (AR) were examined in three groups of adult male rats: 1) intact normal rats, 2) rats castrated at 16 wk of age, and 3) rats castrated at 16 wk of age and given DHT for 1 wk starting at week. 17. All animals were killed at 18 wk of age. Castration caused a decrease (P < 0.05); in the weights of the levator ani and bulbocavernosus muscles. The administration of DHT to the castrated rats increased (P < 0.05) the weights of the levator ani and bulbocavernosus muscles. Castration caused a significant downregulation of AR levels in the bulbocavernosus (P < 0.05) but had no significant effect on AR levels in the levator ani muscle. DHT administration to the castrated group upregulated AR levels in the bulbocavernosus and levator ani muscles. The plantaris muscle did not significantly (P > 0.05) change for any of the treatments. These findings suggest that the effects of castration and androgen replacement differentially affect skeletal muscle mass and AR levels.