Haspin - A mitotic histone kinase required for metaphase chromosome alignment
Haspin - A mitotic histone kinase required for metaphase chromosome alignment
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DOI：
10.4161/cc.4.5.1683
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发表时间：
2005-05-01
期刊：
影响因子：
4.3
通讯作者：
Higgins, JMG
中科院分区：
文献类型：
--
作者：
Dai, J;Higgins, JMG
细胞分裂过程中染色体分离的保真度对于维持基因组稳定性和预防癌症和出生缺陷至关重要。在过去的几年中，已经鉴定和表征了调节该过程的一组关键激酶，包括Aurora、波罗和Nek家族。最近，我们提出一种很少被研究的激酶haspin是这一重要群体的新成员。在有丝分裂期间，haspin被磷酸化，与染色体、中心体和纺锤体缔合，并负责组蛋白H3在苏氨酸-3处的磷酸化。使用RNA干扰的haspin的耗尽阻止了染色体在中期的正常排列，表明haspin在染色体分离中起着至关重要的作用。在这里，我们讨论可能的机制haspin行动和有丝分裂中的组蛋白磷酸化的功能。我们还概述了这些新发现提出的一些问题，并考虑haspin在癌症中可能发挥的作用。
The fidelity of chromosome segregation during cell division is critical to maintain genomic stability and to prevent cancer and birth defects. A key set of kinases that regulates this process has been identified and characterized over the last few years, including the Aurora, Polo and Nek families. Recently we proposed that a little-studied kinase known as haspin is a new member of this important group. During mitosis haspin is phosphorylated, associates with the chromosomes, centrosomes and spindle, and is responsible for phosphorylation of histone H3 at threonine-3. Depletion of haspin using RNA interference prevents normal alignment of chromosomes at metaphase, suggesting that haspin plays a crucial role in chromosome segregation. Here we discuss possible mechanisms of haspin action and the function of histone phosphorylation in mitosis. We also outline some of the questions raised by these new findings and consider what role haspin might play in cancer.