Indoor air pollution and asthma in children.
Indoor air pollution and asthma in children.
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DOI：
10.1513/pats.200908-083rm
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发表时间：
2010-05-01
期刊：
影响因子：
--
通讯作者：
McCormack, Meredith C
中科院分区：
文献类型：
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作者：
Breysse, Patrick N;Diette, Gregory B;McCormack, Meredith C
本文的目的是回顾室内空气污染因素，可以改变哮喘的严重程度，特别是在市中心的环境。虽然有大量文献将环境空气污染与哮喘发病率联系起来，但对室内空气污染对哮喘的影响知之甚少。关注室内环境对儿童来说尤其重要，因为他们可能有90%的时间在室内度过。本文综述了约翰霍普金斯城市环境中儿童哮喘中心的研究以及其他相关的流行病学研究。对已发表文献中暴露结果关系的分析表明，评价室内家庭环境空气污染源作为哮喘发病率危险因素的重要性。城市环境中哮喘发病率的重要室内空气污染决定因素包括颗粒物（特别是粗粒部分），二氧化氮和空气中的小鼠过敏原暴露。避免有害环境暴露是国家和国际哮喘管理指南建议的关键组成部分。该文献表明，改善室内环境以减少颗粒物、NO（2）和小鼠过敏原可能是一种重要的哮喘管理策略。需要更多的研究记录干预措施的有效性，以减少这些暴露并改善哮喘的结果。
The purpose of this article is to review indoor air pollution factors that can modify asthma severity, particularly in inner-city environments. While there is a large literature linking ambient air pollution and asthma morbidity, less is known about the impact of indoor air pollution on asthma. Concentrating on the indoor environments is particularly important for children, since they can spend as much as 90% of their time indoors. This review focuses on studies conducted by the Johns Hopkins Center for Childhood Asthma in the Urban Environment as well as other relevant epidemiologic studies. Analysis of exposure outcome relationships in the published literature demonstrates the importance of evaluating indoor home environmental air pollution sources as risk factors for asthma morbidity. Important indoor air pollution determinants of asthma morbidity in urban environments include particulate matter (particularly the coarse fraction), nitrogen dioxide, and airborne mouse allergen exposure. Avoidance of harmful environmental exposures is a key component of national and international guideline recommendations for management of asthma. This literature suggests that modifying the indoor environment to reduce particulate matter, NO(2), and mouse allergen may be an important asthma management strategy. More research documenting effectiveness of interventions to reduce those exposures and improve asthma outcomes is needed.