Unveiling the Spatiotemporal Diversity of the Endothelium in Development: A Multi-Omics Approach.
Unveiling the Spatiotemporal Diversity of the Endothelium in Development: A Multi-Omics Approach.
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DOI：
10.1161/circresaha.124.324328
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发表时间：
2024-03
影响因子：
20.1
通讯作者：
Roy Jung;Chinmay M. Trivedi
中科院分区：
文献类型：
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作者：
Roy Jung;Chinmay M. Trivedi
内皮细胞形成血管和淋巴管管腔的内壁，是在发育中的血管组织中第一种分化的细胞类型。在哺乳动物胚胎发育过程中，形态发生素梯度影响中胚层内皮前体（称为成血管细胞）的分化和迁移，以形成称为毛细血管丛的原始血管网络。这种原始结构合并并经历形态发生，形成背主动脉和后主静脉，它们是整个血液和淋巴血管系统的基本元素。在整个发育过程中，内皮细胞实现了显着的多样性，表明它们在不同组织中的不同起源和功能作用。 1 然而，血管生物学研究中内皮细胞到达其终末表型的方式和顺序仍未完全表征。
Endothelial cells form the inner lining of the lumen of blood and lymphatic vessels and are the first cell type that differentiates in developing vascular tissue. During mammalian embryonic development, morphogen gradients influence the differentiation and migration of mesodermal endothelial precursors, known as angioblasts, to form a primitive vascular network known as the capillary plexus. This primitive structure coalesces and undergoes morphogenesis to form the dorsal aorta and posterior cardinal vein, foundational elements of the entire blood and lymphatic vascular system. Throughout their development, endothelial cells achieve a remarkable range of diversity, indicative of their varied origins and functional roles in diverse tissues. 1 However, the manner and sequence in which endothelial cells arrive at their terminal phenotypes remain incompletely characterized in vascular biology research.