Isotopic studies of plasma cholesterol of endogenous and exogenous origins.
Isotopic studies of plasma cholesterol of endogenous and exogenous origins.
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内源性和外源性血浆胆固醇的同位素研究。
DOI：
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发表时间：
1955
影响因子：
15.9
通讯作者：
D. Adlersberg
中科院分区：
文献类型：
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作者：
L. Hellman;R. Rosenfeld;M. L. Eidinoff;D. Fukushima;T. Gallagher;C. Wang;D. Adlersberg
本研究旨在比较来自饮食的血浆胆固醇与vAvo中由乙酸盐合成的胆固醇的代谢行为（1）。将同位素碳或氢标记的胆固醇口服给药于人类受试者，并在较长时间内观察其与血浆胆固醇的结合。在某些情况下，通过使用适当标记的乙酸盐和胆固醇同时研究内源性和外源性胆固醇代谢。这些技术也适用于检查的行为，血浆胆固醇在4例高胆固醇血症患者。
This study was undertaken in order to compare the metabolic behavior of plasma cholesterol derived from the diet with that of cholesterol synthesized in vAvo from acetate (1). Cholesterol labeled with either isotopic carbon or hydrogen was administered orally to human subjects and the incorporation into plasma cholesterol was followed over an extended period. In certain instances, both endogenous and exogenous cholesterol metabolism were studied simultaneously by the use of appropriately labeled acetate and cholesterol. These techniques were also applied to an examination of the behavior of plasma cholesterol in four patients with hypercholesterolemia.