Synthesis and applications of HexaPHEMP, a novel biaryl diphosphine ligand
Synthesis and applications of HexaPHEMP, a novel biaryl diphosphine ligand
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DOI：
10.1002/adsc.200390025
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发表时间：
2003-01-01
影响因子：
5.4
通讯作者：
Casy, G
中科院分区：
文献类型：
--
作者：
Henschke, JP;Burk, MJ;Casy, G
以3，4，5-三甲基苯酚为原料，通过五步反应合成了新型联芳基双膦配体1（Hexa-PHEMP）。这种方法还允许通过改变配位磷原子上的芳族基团来微调配体的立体电子性质。在某些不对称氢化方法中，发现含有该配体的催化剂具有比其它含联芳基二膦的催化剂增强的活性和选择性。
The novel biaryldiphosphine ligand 1 (Hexa-PHEMP) has been prepared in five steps from commercially available 3,4,5-trimethylphenol using a concise synthetic route. This approach also allows fine tuning of the ligand's stereoelectronic properties through the variation of the aromatic groups on the ligating phosphorus atoms. In certain asymmetric hydrogenation processes, catalysts containing this ligand were found to have enhanced activity and selectivity over other biaryldiphosphine-containing catalysts.