ENANTIOSEPARATIONS BY CAPILLARY ELECTROPHORESIS USING CHIRAL GLYCOSIDIC SURFACTANTS. II. COMPARISONOF CHIRAL CYCLOHEXYL-ALKYL-β-D-MALTOSIDE SURFACTANTS
ENANTIOSEPARATIONS BY CAPILLARY ELECTROPHORESIS USING CHIRAL GLYCOSIDIC SURFACTANTS. II. COMPARISONOF CHIRAL CYCLOHEXYL-ALKYL-β-D-MALTOSIDE SURFACTANTS
复制标题
使用手性糖苷表面活性剂通过毛细管电泳进行对映体分离 II。
DOI：
10.1081/jlc-100101434
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发表时间：
2000
影响因子：
1.3
通讯作者：
Z. El Rassi
中科院分区：
文献类型：
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作者：
M. Ju;Z. El Rassi
比较了三种糖苷表面活性剂环己基丁基-β- d -麦芽糖苷（CYMAL-4）、环己基戊基-β- d -麦芽糖苷（CYMAL-5）和环己基-己基-β- d -麦芽糖苷（CYMAL-6）对一些丹酰氨基酸和甲基化色氨酸的对映体分离作用。三种CYMAL表面活性剂具有相同的手性麦芽糖头基团，但疏水尾部的长度不同。增加疏水尾部的长度似乎使表面活性剂的最佳浓度向较低的浓度值移动，从而获得最大的对映体分辨率。为了扩大表面活性剂的最佳浓度范围，以达到最大的对映体分辨率，引入并评价了混合的CYMAL表面活性剂体系。它们由CYMAL-6与环己基甲基-β- d -麦芽糖苷（CYMAL-1）或环己基乙基-β- d -麦芽糖苷（CYMAL-2）混合组成。
Three different glycosidic surfactants, namely cyclohexyl-butyl-β-D-maltoside (CYMAL-4), cyclohexyl-pentyl-β-D-maltoside (CYMAL-5), and cyclohexyl-hexyl-β-D-maltoside (CYMAL-6), were compared in the enantioseparation of some dansyl amino acids and methylated tryptophans. The three CYMAL surfactants have the same chiral maltoside head group but differ in the length of the hydrophobic tail. Increasing the length of the hydrophobic tail seems to shift the optimum surfactant concentration for maximum enantioresolution towards lower concentration values. In order to extend the range of optimum surfactant concentration over which maximum enantioresolution can be achieved, mixed CYMAL surfactant systems were introduced and evaluated. They consisted of mixing CYMAL-6 with either cyclohexyl-methyl-β-D-maltoside (CYMAL-1) or cyclohexyl-ethyl-β-D-maltoside (CYMAL-2).