A decrease of ripples precedes seizure onset in mesial temporal lobe epilepsy
A decrease of ripples precedes seizure onset in mesial temporal lobe epilepsy
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内侧颞叶癫痫发作前波纹减少
DOI：
10.1016/j.expneurol.2016.07.015
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发表时间：
2016
影响因子：
5.3
通讯作者：
Chen Zhong
中科院分区：
文献类型：
--
作者：
Xu Cenglin;Wang Shuang;Wang Yi;Lin Kang;Pan Gang;Xu Zhenghao;Gonzalez-Martinez Jorge;Gao Feng;Wu Xiaohua;Zhang Shihong;Bulacio Juan C.;Najm Imad M.;Luo Jianhong;Hu Weiwei;Wu Zhaohui;So Norman K.;Chen Zhong
高频振荡（hfo）是有希望的癫痫灶生物标志物；然而，它们在孕前期的特征变化尚不清楚。本研究记录了小鼠匹罗卡品模型以及内侧颞叶癫痫（mTLE）和新皮质癫痫患者的前脑HFOs，并采用HFOs自动检测方法进行检测。10只小鼠共记录了16次低电压快速发作（LVF）和53次高同步发作（HYP）。在LVF和HYP发作前1分钟，波纹率（80-250 Hz）下降，这主要是由于II型波纹（与癫痫样放电无关）而不是I型波纹（与癫痫样活动叠加）的减少。而在LVF发作前1 min，纹波率在40 s时达到峰值。此外，在9例mTLE患者的12次癫痫发作中也观察到“纹波减少”现象，但在新皮质癫痫中没有观察到。这些结果表明，波纹可能有助于了解mTLE的icogenesis机制，并且在LVF和HYP发作前一分钟内波纹变化的不同模式也可能有助于癫痫发作类型的诊断。
High-frequency oscillations (HFOs) are promising biomarkers for epileptic foci; however, their characteristic changes during the preictal period remain unclear. Here, the preictal HFOs were recorded and detected by an automated HFOs detection method in the mouse pilocarpine model as well as in patients with mesial temporal lobe epilepsy (mTLE) and neocortical epilepsy. A total of sixteen low-voltage fast (LVF) and fifty-three hypersynchronous-onset (HYP) seizures were recorded in ten mice. The rate of ripples (80–250 Hz) decreased during 1 min before the onset of LVF and HYP seizures, which was primarily due to the reduction of type II (independent of epileptiform discharges) rather than type I ripples (superimposed on epileptiform activities). The ripple rate decreased until 30 s before HYP seizure, whereas it increased with a peak at 40 s during the 1 min preictal period of LVF seizures. Furthermore, the “ripple reduction” phenomenon was also observed in all twelve seizures from nine patients with mTLE but not in neocortical epilepsy. These results indicate that ripples may potentially be helpful for understanding the mechanisms of ictogenesis in mTLE, and the different modes of ripple changes during the minute before LVF and HYP seizures might also be beneficial for the diagnosis of seizure types.