LTP after stress: up or down?
LTP after stress: up or down?
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DOI：
10.1155/2007/93202
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发表时间：
2007
影响因子：
3.1
通讯作者：
Krugers HJ
中科院分区：
文献类型：
--
作者：
Joëls M;Krugers HJ
当一个有机体暴露在压力环境中时，大脑中的皮质类固醇水平会上升。这种上升对行为表现有影响，包括记忆的形成。在过去的几十年中，已经清楚的是，皮质类固醇水平的升高也伴随着海马长时程增强（LTP）的减少。然而，最近的研究表明，压力并不导致LTP的普遍抑制。许多因素，包括应激的类型、应激反应的阶段、研究的区域、LTP的类型和生物体的生活史，决定了LTP将向哪个方向改变。
When an organism is exposed to a stressful situation, corticosteroid levels in the brain rise. This rise has consequences for behavioral performance, including memory formation. Over the past decades, it has become clear that a rise in corticosteroid level is also accompanied by a reduction in hippocampal long-term potentiation (LTP). Recent studies, however, indicate that stress does not lead to a universal suppression of LTP. Many factors, including the type of stress, the phase of the stress response, the area of investigation, type of LTP, and the life history of the organism determine in which direction LTP will be changed.