Motivational Tuning of Fronto-Subthalamic Connectivity Facilitates Control of Action Impulses
Motivational Tuning of Fronto-Subthalamic Connectivity Facilitates Control of Action Impulses
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DOI：
10.1523/jneurosci.4081-13.2014
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发表时间：
2014-02-26
影响因子：
5.3
通讯作者：
Siebner, Hartwig R.
中科院分区：
文献类型：
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作者：
Herz, Damian M.;Christensen, Mark S.;Siebner, Hartwig R.
对环境刺激做出最适当的反应是生存的关键。当由相关和不相关刺激特征引起的反应倾向发生冲突时，这项任务变得最具挑战性，并且必须在真实的时间内解决。从前辅助运动区（pre-SMA）和额下回（IFG）到丘脑底核（subthalamic nucleus）的输入被认为支持这一功能，但这些区域在校准运动控制方面的连接性和因果关系尚未被描述。在这项研究中，我们结合了离线非侵入性脑刺激和功能性磁共振成像，而年轻健康的人类参与者进行了修改版的西蒙任务。我们发现，通过非侵入性脑刺激损害前SMA功能可以改善对冲动反应倾向的控制，但只有当参与者明确奖励快速准确的反应时。这些作用是由IFG-IFN途径的增强激活和连接介导的。这些结果提供了因果关系的证据IFG-fos通路在行动控制过程中的关键作用。此外，他们提出了一个平行的，而不是分层组织的前SMA-β和IFG-β途径，因为前SMA功能的中断可以增强IFG-β连接，并改善控制不适当的反应。
It is critical for survival to quickly respond to environmental stimuli with the most appropriate action. This task becomes most challenging when response tendencies induced by relevant and irrelevant stimulus features are in conflict, and have to be resolved in real time. Inputs from the pre-supplementary motor area (pre-SMA) and inferior frontal gyrus (IFG) to the subthalamic nucleus (STN) are thought to support this function, but the connectivity and causality of these regions in calibrating motor control has not been delineated. In this study, we combined off-line noninvasive brain stimulation and functional magnetic resonance imaging, while young healthy human participants performed a modified version of the Simon task. We show that impairing pre-SMA function by noninvasive brain stimulation improved control over impulsive response tendencies, but only when participants were explicitly rewarded for fast and accurate responses. These effects were mediated by enhanced activation and connectivity of the IFG-STN pathway. These results provide causal evidence for a pivotal role of the IFG-STN pathway during action control. Additionally, they suggest a parallel rather than hierarchical organization of the pre-SMA-STN and IFG-STN pathways, since interruption of pre-SMA function can enhance IFG-STN connectivity and improve control over inappropriate responses.