Chronic stress selectively reduces hippocampal volume in rats: a longitudinal magnetic resonance imaging study.
Chronic stress selectively reduces hippocampal volume in rats: a longitudinal magnetic resonance imaging study.
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DOI：
10.1097/wnr.0b013e328332bb09
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发表时间：
2009-11-25
期刊：
影响因子：
1.7
通讯作者：
Helmstetter FJ
中科院分区：
文献类型：
--
作者：
Lee T;Jarome T;Li SJ;Kim JJ;Helmstetter FJ
无法控制的压力导致海马体积缩小的概念在创伤后应激障碍文献中仍然存在争议，因为人类研究无法辨别影响的因果关系。在这里，我们解决了这个问题，采用结构磁共振成像在大鼠海马和其他大脑区域测量之前和之后的压力。慢性束缚应激使海马体积减少约3%，而在对照组大鼠中未观察到。这种降低与基线海马体积或体重无显著相关性。总前脑体积和其他脑区和肾上腺的大小都不受压力的影响。这个纵向的，受试者内设计的研究提供了直接的证据，海马是不同的脆弱性和敏感性的慢性压力。
The notion of uncontrollable stress causing reduced hippocampal size remains controversial in the posttraumatic stress disorder literature because human studies cannot discern the causality of effect. Here, we addressed this issue by employing structural magnetic resonance imaging in rats to measure the hippocampus and other brain regions before and after stress. Chronic restraint stress produced approximately 3% reduction in hippocampal volume, which was not observed in control rats. This decrease was not signficantly correlated with baseline hippocampal volume or body weight. Total forebrain volume and the sizes of the other brain regions and adrenal glands were all unaffected by stress. This longitudinal, within-subjects design study provides direct evidence that the hippocampus is differentially vulnerable and sensitive to chronic stress.