Modification of circadian body temperature rhythm during the luteal menstrual phase: Role of melatonin
Modification of circadian body temperature rhythm during the luteal menstrual phase: Role of melatonin
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DOI：
10.1152/jappl.1996.80.1.25
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发表时间：
1996-01-01
影响因子：
3.3
通讯作者：
Yen, SSC
中科院分区：
文献类型：
--
作者：
Cagnacci, A;Soldani, R;Yen, SSC
在卵泡早期（FP）的女性中，夜间褪黑激素的升高占夜间核心体温（T-c）下降的40%。在7个正常的周期妇女，T-c和褪黑激素的昼夜节律的FP与黄体期（LP）进行了比较。此外，在这两个阶段的T-C响应白天褪黑激素管理进行了研究。两个月经期的褪黑素水平相当，但LP的夜间褪黑素起效时间延迟90 min（P < 0.01）。这伴随着T-c昼夜节律最低点的延迟（P < 0.002），24小时平均值升高0.3 ℃（P < 0.005），幅度钝化40%（P < 0.002）。这种衰减的昼夜T-C在LP妇女复制在两个雌激素治疗的性腺功能减退的妇女，醋酸甲羟孕酮的管理。白天给予褪黑激素（2.5mg）降低FP期间的T-c（P < 0.01），但对LP无效。目前的数据表明，在LP中，与高孕酮水平相关的减弱和相位延迟的昼夜T-c节律可能部分是由于褪黑激素的作用降低。
In women during early follicular phase (FP), the rise of melatonin at night accounts for 40% of the nocturnal core body temperature (T-c) decline. In seven normal-cycling women, the circadian rhythms of T-c and melatonin of the FP were compared with those of the luteal phase (LP). In addition, in both phases the T-c response to daytime melatonin administration was investigated. Melatonin levels were comparable during the two menstrual phases, but the nocturnal melatonin onset was delayed by 90 min in the LP (P < 0.01). This was accompanied by a delay of the nadir of the T-c circadian rhythm (P < 0.002), a 0.3 degrees C elevation (P < 0.005) of the mean 24-h value, and a 40% blunting (P < 0.002) of the amplitude. This attenuation of circadian T-c in LP women was replicated in two estrogen-treated hypogonadal women by the administration of medroxyprogesterone acetate. The daytime administration of melatonin (2.5 mg) decreased T-c during the FP (P < 0.01) but was ineffective in the LP Present data indicate that in LP, in association with high progesterone levels, an attenuated and phase-delayed circadian T-c rhythm may, in part, be due to a reduced effect of melatonin.