How well do blood flow imaging and collaterals on angiography predict brain at risk?
How well do blood flow imaging and collaterals on angiography predict brain at risk?
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DOI：
10.1212/wnl.0b013e3182695904
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发表时间：
2012-09-01
期刊：
影响因子：
9.9
通讯作者：
Sanossian, Nerses
中科院分区：
文献类型：
--
作者：
Liebeskind, David S.;Sanossian, Nerses
由于血管内治疗作为恢复急性卒中患者血流的主要方法，需要开发更好的患者选择方法。在血管内治疗之前获得的血流和血管造影结果的非侵入性研究可能有助于确定有梗死和出血性转化风险的脑区域，这两者在很大程度上取决于脑缺血的严重程度。在血运重建之前表征缺血严重程度的侧支血流和灌注的病理生理学测量可以优化急性卒中决策，目前由来自缺乏成像的人群研究的任意时间参数驱动。神经病学（R）2012; 79（增刊1）：S105-S109
As endovascular therapy emerges as a principal approach to restore blood flow in the setting of acute stroke, better methods of patient selection need to be developed. Noninvasive studies of blood flow and angiographic results acquired prior to endovascular therapy may help determine areas of brain at risk of infarction and hemorrhagic transformation, both largely determined by the severity of cerebral ischemia. Pathophysiologic measures of collateral flow and perfusion that characterize ischemic severity prior to revascularization may optimize acute stroke decision-making, currently driven by arbitrary time parameters derived from population studies devoid of imaging. Neurology (R) 2012; 79 (Suppl 1):S105-S109