Influence of exogenous estrogen receptor ligands on uterine leiomyoma:: Evidence from an in vitro/in vivo animal model for uterine fibroids
Influence of exogenous estrogen receptor ligands on uterine leiomyoma:: Evidence from an in vitro/in vivo animal model for uterine fibroids
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DOI：
10.2307/3454314
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发表时间：
2000-10-01
影响因子：
10.4
通讯作者：
Walker, CL
中科院分区：
文献类型：
--
作者：
Hunter, DS;Hodges, LC;Walker, CL
子宫平滑肌瘤在人群中的显著频率引起了对肿瘤病因中环境因素参与的可能性的质疑。近年来，内分泌干扰物与激素相关癌症的急剧增加有关，虽然它们可能参与的机制尚不清楚，但在这一发病机制中，内分泌干扰物是显著的嫌疑人。使用Eker大鼠模型的研究表明，子宫平滑肌瘤可能对雌激素受体的调节具有增强的敏感性。这种敏感性可能使这些肿瘤成为外源性雌激素受体配体破坏的目标。缺乏外源性化合物在平滑肌瘤中致病作用的直接证据；然而，可以证明，诸如有机氯农药、膳食类黄酮、植物提取物和治疗性抗雌激素等多种药物在子宫肌组织中具有雌激素激动剂或拮抗剂的功能。该模型的使用将有助于确定外源性雌激素受体调节剂对子宫平滑肌瘤的影响，并将允许评估治疗干预策略。
The remarkable frequency of uterine leiomyoma in the human population calls into question the potential for the participation of environmental factors in tumor etiology. Having been implicated in the dramatic rise in hormone-related cancers in recent years, endocrine disrupters are salient suspects in this pathogenesis, although the mechanism by which they might participate is unclear. Investigations using the Eker rat model show that uterine leiomyoma may have an enhanced sensitivity to modulation via the estrogen receptor. This sensitivity could make these tumors a target for disruption by exogenous estrogen receptor ligands. Direct evidence for a pathogenic role of exogenous compounds in leiomyomas is lacking; however, it can be demonstrated that such diverse agents as organochlorine pesticides, dietary flavonoids, botanical extracts, and therapeutic antiestrogens have either estrogen agonist or antagonist function in myometrial tissues. The use of this model will help define the impact of exogenous estrogen receptor modulators on uterine leiomyoma and will permit the evaluation of strategies for therapeutic intervention.