SERIES "MATRIX METALLOPROTEINASES IN LUNG HEALTH AND DISEASE" Edited by J. Muller-Quernheim and O. Eickelberg Number 8 in this Series Interaction of matrix metalloproteinases with pulmonary pollutants
SERIES "MATRIX METALLOPROTEINASES IN LUNG HEALTH AND DISEASE" Edited by J. Muller-Quernheim and O. Eickelberg Number 8 in this Series Interaction of matrix metalloproteinases with pulmonary pollutants
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DOI：
10.1183/09031936.00195811
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发表时间：
2012-04-01
影响因子：
24.3
通讯作者：
Boczkowski, J.
中科院分区：
文献类型：
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作者：
Dagouassat, M.;Lanone, S.;Boczkowski, J.
空气污染物包括任何可能危害人类、动物、植物或材料的大气物质。各种空气污染物的报告，在其物理化学特性不同。它们可以分为四类：气体污染物（如：G.臭氧，二氧化硫，氮氧化物，一氧化碳和挥发性有机化合物），持久性有机污染物，重金属（例如，G.镉、铅和汞）和颗粒物（粗、细和超细）。这些污染物可到达呼吸系统，引起肺部和/或全身效应。这些效应包括炎症、组织重塑和致癌作用：基质金属蛋白酶（MMP）在所有这些现象中发挥关键作用，因为它们对基质重塑和炎症及细胞信号传导的调节具有广泛的影响。此外，由于MMPs的表达和活性可以由这些刺激物诱导，因此提出了MMPs可能参与污染物对健康影响的假设。到目前为止，MMPs在这些影响中的作用仅针对某些污染物和MMPs的有限选择（主要是MMP-1，-2，-9和-12）进行了研究，而MMP诱导/激活与健康影响之间的联系的证据仍然很少。因此，需要进行更多的研究，以更好地了解MMPs对空气污染相关健康影响的影响。
An air pollutant consists of any atmospheric substance that may harm humans, animals, vegetation or material. Various air pollutants have been reported, differing in their physicochemical characteristics. They can be grouped into four categories: gaseous pollutants (e. g. ozone, sulfur dioxide, oxides of nitrogen, carbon monoxide and volatile organic compounds), persistent organic pollutants, heavy metals (e. g. cadmium, lead and mercury) and particulate matter (coarse, fine and ultrafine). These pollutants can reach the respiratory system, eliciting pulmonary and/or systemic effects. These effects include inflammation, tissue remodelling and carcinogenesis: all phenomena where matrix metalloproteases (MMPs) play critical roles, given their broad effects on matrix remodelling and modulation of inflammation and cell signalling. Moreover, since expression and activity of MMPs can be induced by such stimuli, the hypothesis has been raised that MMPs could be involved in the health effects of pollutants. Until now, the implication of MMPs in these effects has been studied only for some pollutants and for a restricted selection of MMPs (mainly MMP-1, -2, -9 and -12), while evidence for a link between MMP induction/activation and health effects remains scarce. A larger number of studies is, therefore, needed in order to better understand the implication of MMPs in health effects associated with air pollution.