Synthesis of Hexahydro-thiazolo[3,2-a]pyridin-5-ones and Hexahydropyrido[2,1-b][1,3]thiazin-6-ones Systems by Radical-Initiated Cyclization of 3-Alkenoyl-2-methylene-1,3-thiazolidines and -tetrahydro-1,3-thiazines
Synthesis of Hexahydro-thiazolo[3,2-a]pyridin-5-ones and Hexahydropyrido[2,1-b][1,3]thiazin-6-ones Systems by Radical-Initiated Cyclization of 3-Alkenoyl-2-methylene-1,3-thiazolidines and -tetrahydro-1,3-thiazines
复制标题
3-烯酰基-2-亚甲基自由基引发环化合成六氢噻唑并[3,2-a]吡啶-5-酮和六氢吡啶并[2,1-b][1,3]噻嗪-6-酮体系
DOI：
10.1055/s-2001-9744
复制
发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Joanna Flisiska
中科院分区：
文献类型：
--
作者：
Stanisaw Leniak;Joanna Flisiska
报道了一种新的合成六氢噻唑并[3，2-a]吡啶-5-酮6和六氢吡啶并[2，1-B][1，3]噻嗪-6-酮7的方法。2-甲基-4，5-二氢噻唑（1）或2-甲基-5，6-二氢-4H-[1，3]噻嗪（2）分别与a，b-不饱和酰氯进行酰化反应。产物3和4与氢化三丁基锡发生自由基反应，环化为双环体系。
A new and efficient method for the synthesis of hexahydro-thiazolo [3, 2-a] pyridin-5-ones 6 and hexahydro-pyrido [2, 1-b][1, 3] thiazin-6-ones 7 has been developed. The acylation of 2-methyl-4, 5-dihydro-thiazole (1) or 2-methyl-5, 6-dihydro-4H-[1, 3] thiazine (2), with a, b-unsaturated acid chlorides was performed. The products 3 and 4 were cyclized to bicyclic systems in a free radical reaction with tributyltin hydride.