Converging methods in studying attention-deficit/hyperactivity disorder: What can we learn from neuroimaging and genetics?
Converging methods in studying attention-deficit/hyperactivity disorder: What can we learn from neuroimaging and genetics?
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DOI：
10.1017/s0954579408000539
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发表时间：
2008-09-01
影响因子：
3.3
通讯作者：
Durston, Sarah
中科院分区：
文献类型：
--
作者：
Durston, Sarah
本文讨论了如何收敛的方法可能会形成一个强大的工具，在解开神经生物学的注意缺陷多动障碍（ADHD）。综合多学科的研究结果可以告诉我们不同的神经生物学和认知机制如何在典型和非典型发育中联系在一起。这种方法的例子进行了讨论：结合家庭和遗传的方法与解剖神经影像学说明如何映射家族效应可以使我们更接近理解ADHD的神经生物学。功能性神经影像学检查令人信服地将这种疾病中的认知问题与额纹状体功能联系起来，但也表明其他系统可能参与了ADHD的一些症状。结合这些发现提出了新的研究途径，如额小脑网络的作用。此外，研究结果可能有实际应用：本文讨论了一个例子，如何收敛的证据表明，在ADHD纹状体失调可能的治疗方向，现在正在探索功能成像研究。
This paper discusses how converging methods may form a powerful tool in unraveling the neurobiology of attention- deficit/hyperactivity disorder (ADHD). Integrating findings from multiple disciplines can inform us on how different neurobiological and cognitive mechanisms tie together in both typical and atypical development. Examples are discussed of this approach: combining family and genetic approaches with anatomical neuroimaging illustrates how mapping familial effects can bring us closer to understanding the neurobiology of ADHD. Functional neuroimaging hats convincingly linked cognitive problems in this disorder with frontostriatal funcitoning, but also shows that other systems may be involved in some of the symptoms of ADHD. Combining these findings has suggested new avenues for investigation, such as the role of frontocerebellar networks. Furthermore, findings may have practical applications: this paper discusses an example of how converging evidence of striatal dysregulation in ADHD suggests possible directions for treatment that are now being explored in functional imaging studies.