Skeletal muscle satellite cells and adult myogenesis
Skeletal muscle satellite cells and adult myogenesis
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DOI：
10.1016/j.ceb.2007.09.012
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发表时间：
2007-12-01
影响因子：
7.5
通讯作者：
Rudnicki, Michael A.
中科院分区：
文献类型：
--
作者：
Le Grand, Fabien;Rudnicki, Michael A.
距最初描述已有 46 年，专注于典型成体肌源性祖细胞（骨骼肌卫星细胞）的研究仍然是一个不断发展的领域。最近的出版物揭示了卫星细胞生物学的许多新方面，从它们的发育寿命到它们作为成体骨骼肌中主要的自我更新肌源干细胞的作用，最后到它们在衰老过程中的损失。卫星细胞的生肌潜力受到特定配对盒和 bHLH 转录因子的分子控制，这些转录因子的紧密协调平衡可实现有效的骨骼肌再生。新的报告还证明了卫星细胞与血管的关系以及与这两个谱系相关的干细胞亚群的高生肌潜力。
Research focusing on the canonical adult myogenic progenitor, the skeletal muscle satellite cell, is still an ever-growing field 46 years from their initial description. Recent publications revealed numerous new aspects of satellite cell biology, starting from their developmental life to their role as the principal self-renewing myogenic stem cell in adult skeletal muscle and finally their loss during aging. The myogenic potential of satellite cells is under the molecular control of specific paired-box and bHLH transcription factors whose tightly orchestrated balance accounts for an effective skeletal muscle regeneration. New reports also demonstrate satellite cells relationships with blood vessels and the high myogenic potential of stem cell subsets related to both lineages.