High IL-21 receptor expression and apoptosis induction by IL-21 in follicular lymphoma
High IL-21 receptor expression and apoptosis induction by IL-21 in follicular lymphoma
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DOI：
10.1016/j.canlet.2007.06.001
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发表时间：
2007-10-28
期刊：
影响因子：
9.7
通讯作者：
Kamihira, Shimeru
中科院分区：
文献类型：
--
作者：
Akamatsu, Norihiko;Yamada, Yasuaki;Kamihira, Shimeru
我们调查了白血病和淋巴瘤中的IL-21受体（IL-21 R），发现滤泡性淋巴瘤细胞显示异常高的IL-21 R表达。值得注意的是，IL-21根据细胞来源显示出不同的作用：在伯基特淋巴瘤细胞系和成人T细胞白血病/淋巴瘤细胞系中刺激生长，但在具有t（14-，18）（q32; q2 l）（滤泡性淋巴瘤的标志物核型）的B淋巴瘤细胞系中诱导凋亡。IL-21激活caspase-8和caspase-3并降低线粒体膜电位。更重要的是，IL-21降低Bcl-2的表达，但增加Bax的表达。这些结果支持一种新的治疗方法，使用IL-21/IL-21 R系统在滤泡性淋巴瘤。(C)2007爱思唯尔爱尔兰有限公司保留所有权利。
We surveyed IL-21 receptor (IL-21R) in leukemia and lymphoma and found that follicular lymphoma cells showed exceptionally high IL-21R expression. Notably, IL-21 showed divergent effects depending on the cell origin: growth stimulation in Burkitt lymphoma cell lines and adult T cell leukemia/lymphoma cell lines but induction of apoptosis in B lymphoma cell lines with t(l4-,l8)(q32;q2l), a marker karyotype of follicular lymphoma. IL-21 activated caspase-8 and -3 and reduced mitochondrial membrane potential. More importantly, IL-21 decreased Bcl-2 expression but increased Bax expression. These results support a new therapeutic approach using the IL-21/IL-21R system in follicular lymphoma. (C) 2007 Elsevier Ireland Ltd. All rights reserved.