Electroencephalographic measures of regional hemispheric activity in offspring at risk for depressive disorders
Electroencephalographic measures of regional hemispheric activity in offspring at risk for depressive disorders
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DOI：
10.1016/j.biopsych.2004.11.015
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发表时间：
2005-02-15
影响因子：
10.6
通讯作者：
Weissman, MM
中科院分区：
文献类型：
--
作者：
Bruder, GE;Tenke, CE;Weissman, MM
背景资料：脑电图（EEG）研究发现抑郁症患者存在异常的区域半球不对称性，这被认为是抑郁症的易感性标志。在一项纵向高危研究中，对抑郁症或非抑郁症先证者的成年后代进行静息EEG测量。每个半球12个同源部位的脑电图在父母双方（n = 18）、父母一方（n = 40）或父母双方（n = 29）均患有重度抑郁症（MDD）的右利手后代中分析（数字链接耳朵参考）。双亲均患有MDD的后代在内侧部位表现出更大的α不对称性，活动相对较少（更多的后代有一个或没有患有MDD的父母。相对较少的左额叶（α）超过右中央和顶叶区域，与侧部活动相比，与后代的终身MDD相关，但与父母的MDD无关。与父母双方有MDD的后代也表现出显着更大的前向后增加α与闭上眼睛相比，有一个或没有父母与一个MDD.Conclusions：阿尔法不对称指示右顶叶颞叶功能减退，以前报道的杉木抑郁的青少年和成人，并提高前向后梯度的α存在于高风险的后代父母一致的MDD。
Background: Electroencephalographic (EEG) studies have found abnormal regional hemispheric asymmetries in depressive disorders which have been hypothesized to be vulnerability markers for depression, In a longitudinal high-risk study, resting EEG was measured in primarily adult offspring of depressed or nondepressed probands.Methods:. Electroencephalograms from 12 homologous sites over each hemisphere (digitally linked-ears reference) were analyzed in right-handed offspring for whom both parents (n = 18), one parent (n = 40), or neither parent (n = 29) had a major depressive disorder (MDD).Results: Offspring with both parents having MDD showed greater alpha asymmetry at medial sites, with relatively less activity (more offspring having one or no parent with MDD. Relatively less left frontal alpha) over fight central and parietal regions, compared with of activity at lateral sites was associated with lifetime MDD in offspring but not with parental MDD. Offspring with both parents having a MDD also showed markedly greater anterior-to-posterior increase in alpha with eyes closed compared with those with one or no parent with a MDD.Conclusions: Alpha asymmetry indicative of right parietotemporal hypoactivity, previously reported fir depressed adolescents and adults, and heightened anterior-to-posterior gradient of alpha are present in high-risk offspring having parents concordant for MDD.