The association between the Survivin A9194G exon polymorphisms and papillary thyroid carcinoma risk in the Han Chinese population
The association between the Survivin A9194G exon polymorphisms and papillary thyroid carcinoma risk in the Han Chinese population
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DOI：
10.1016/j.prp.2013.01.004
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发表时间：
2013-01-01
影响因子：
2.8
通讯作者：
Wang, Xiu-Yun
中科院分区：
文献类型：
--
作者：
Wang, Ying-Xue;Li, Ming-Long;Wang, Xiu-Yun
细胞凋亡的失调在肿瘤的发生发展中起着关键作用。本研究旨在探讨细胞凋亡相关基因Survivin A9194G单核苷酸多态性(SNPs)与甲状腺乳头状癌(Pit)易感性的关系。为探讨Survivin A9194G基因多态性与PTC易感性的关系，采用DNA测序的方法，对126例PTC患者和198例对照组进行了病例对照研究。并分析其基因频率分布及其与临床病理特征的关系。我们发现Survivin A9194G基因型患上甲状腺癌的风险降低(P=0.003；优势比(OR)=0.56)。此外，与AA和AG表型的PTC相比，GG基因型的甲状腺癌在年轻患者和病理分期较低的患者中显著更常见。综上所述，Survivin(A9194G)基因多态性在PTC的易感性中起保护作用。然而，需要更大样本量的进一步调查来支持我们的结果。(C)2013年爱思唯尔股份有限公司。版权所有。
The dysregulation of apoptosis plays a key role in carcinogenesis. This study was designed to investigate the association of apoptosis-related gene survivin A9194G single-nucleotide polymorphisms (SNPs) with papillary thyroid carcinoma (Pit) susceptibility. A case-control study of 126 patients and 198 controls was performed to investigate the association between Survivin A9194G polymorphisms and PTC susceptibility by polymerase chain reaction (PCR) following DNA sequencing methods. Moreover, the distribution of genotype frequency and the association of genotype with clinicopathologic characteristics were analyzed. We found that the survivin A9194G genotype was at a decreased risk of PTC (P = 0.003; odds ratio (OR) = 0.56). Furthermore, compared to the PTCs of the AA and AG phenotypes, the GG genotype thyroid cancers were significantly more common in younger patients and in cases of lower pathologic stages. In conclusion, the survivin (A9194G) polymorphism was found to play a protective role in the susceptibility to PTC. Nevertheless, further investigation with a larger sample size is needed to support our results. (C) 2013 Elsevier GmbH. All rights reserved.