Molecular theory of hydrophobic mismatch between lipids and peptides
Molecular theory of hydrophobic mismatch between lipids and peptides
复制标题
脂质和肽之间疏水错配的分子理论
DOI：
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
M. Schick
中科院分区：
文献类型：
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作者：
D. Duque;Xiao;K. Katsov;M. Schick
利用脂质的微观模型，理论上研究了完整蛋白质的跨膜α螺旋的疏水长度d和它们所跨越的膜的疏水厚度Dh之间的失配的影响。特别是，我们研究了依赖于一个刚性的，完整的，肽的疏水长度和体积分数的层状相的周期。我们发现，当插入一个短肽，如D DH时，周期会减小。这种效应是由于刚性肽取代了可延伸的脂质尾部。随着肽长度的增加，片层周期继续增加，但速度较慢，最终可能会减少。未能结合和跨越膜的肽的量随着疏水错配的大小而增加|d−Dh|.我们对这些行为进行了解释，都与实验结果雅阁。预测是为T…
Effects of the mismatch between the hydrophobic length d, of transmembrane alpha helices of integral proteins and the hydrophobic thickness, Dh, of the membranes they span are studied theoretically utilizing a microscopic model of lipids. In particular, we examine the dependence of the period of a lamellar phase on the hydrophobic length and volume fraction of a rigid, integral, peptide. We find that the period decreases when a short peptide, such that d Dh, is inserted. The effect is due to the replacement of extensible lipid tails by rigid peptide. As the peptide length is increased, the lamellar period continues to increase, but at a slower rate, and can eventually decrease. The amount of peptide which fails to incorporate and span the membrane increases with the magnitude of the hydrophobic mismatch |d−Dh|. We explicate these behaviors which are all in accord with experiment. Predictions are made for t...
影响因子：
2.9
作者：
Killian, JA;Salemink, I;Greathouse, DV
通讯作者：
Greathouse, DV
影响因子：
3.4
作者：
Harroun, TA;Heller, WT;Huang, HW
通讯作者：
Huang, HW