IMMUNE RESPONSIVENESS AND PARASITE-SPECIFIC ANTIBODY-LEVELS IN HUMAN HEPATOBILIARY DISEASE ASSOCIATED WITH OPISTHORCHIS-VIVERRINI INFECTION
IMMUNE RESPONSIVENESS AND PARASITE-SPECIFIC ANTIBODY-LEVELS IN HUMAN HEPATOBILIARY DISEASE ASSOCIATED WITH OPISTHORCHIS-VIVERRINI INFECTION
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DOI：
10.1111/j.1365-2249.1991.tb08151.x
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发表时间：
1991-05-01
影响因子：
4.6
通讯作者：
MAIRIANG, P
中科院分区：
文献类型：
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作者：
HASWELLELKINS, MR;SITHITHAWORN, P;MAIRIANG, P
猫尾睾吸虫感染与人类肝胆疾病和胆管癌有关，但免疫应答在感染发病机制中的作用尚不清楚。 在这里，超声检查胆道的居民从流行的社区。 对不相关抗原的迟发型超敏反应，以及该组血清中的吸虫特异性IgG和伊加水平也进行了检查。 免疫学参数，感染强度和放射学测量变量之间的关系的报告。 对无关抗原的免疫应答不随寄生虫感染或疾病状态的强度而变化。 在所有变量中，IgG水平在疾病病例中与正常受试者相比最显著升高，并且与胆囊大小和功能障碍密切相关。 这与免疫病理机制参与后睾吸虫病的假设一致，并表明抗体水平可能有助于筛查人群中的吸虫相关肝胆疾病。
Opisthorchis viverrini infection is associated with human hepatobiliary disease and cholangiocarcinoma, but the role of the immune response in the pathogenesis of infection is unclear. Here ultrasonography was used to examine the biliary tracts of residents from an endemic community. Delayed-type hypersensitivity responses to unrelated antigens, and fluke-specific IgG and IgA levels in serum of this group were also examined. Relationships between immunological parameters, intensity of infection and radiologically measured variables are reported. Immune responsiveness to unrelated antigens did not vary with intensity of parasite infection or disease status. Of all the variables, IgG levels were most markedly elevated in disease cases compared with normal subjects and were closely associated with gall bladder size and dysfunction. This is consistent with the hypothesis that an immunopathologic mechanism is involved in opisthorchiasis and suggests that antibody levels may be useful in screening populations for fluke-associated hepatobiliary disease.