Six-helix bundles designed from DNA
Six-helix bundles designed from DNA
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DOI：
10.1021/nl050084f
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发表时间：
2005-04-01
期刊：
影响因子：
10.8
通讯作者：
Seeman, NC
中科院分区：
文献类型：
--
作者：
Mathieu, F;Liao, SP;Seeman, NC
我们提出了一个设计的环状DNA基序，由六个DNA双螺旋，彼此连接在两个交叉位点。当交叉点被7或14个核苷酸对分开时，每圈具有10.5个核苷酸对的DNA双螺旋促进DNA双交叉分子的编程以形成六边形对称排列。我们证明了原子力显微镜良好的六角形六螺旋束图案在1D和2D阵列。
We present a designed cyclic DNA motif that consists of six DNA double helices that are connected to each other at two crossover sites. DNA double helices with 10.5 nucleotide pairs per turn facilitate the programming of DNA double crossover molecules to form hexagonally symmetric arrangements when the crossover points are separated by seven or fourteen nucleotide pairs. We demonstrate by atomic force microscopy well-formed arrays of hexagonal six-helix bundle motifs both in 1D and in 2D.