Long-term trajectories of ambulatory impairment in multiple sclerosis.
Long-term trajectories of ambulatory impairment in multiple sclerosis.
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DOI：
10.1177/13524585231187521
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发表时间：
2023-09
影响因子：
5.8
通讯作者：
Briggs, Farren B. S.
中科院分区：
文献类型：
--
作者：
Gunzler, Douglas D.;De Nadai, Alessandro S.;Miller, Deborah M.;Ontaneda, Daniel;Briggs, Farren B. S.
关键词：
多发性硬化症(MS)的运动障碍是一种常见而复杂的表现，其纵向模式尚不清楚。为了确定普通MS患者和早期疾病患者(≤发病5年后)的纵向步行速度轨迹，识别具有相似模式的亚组，并检查与个体属性的关联。采用回溯性队列研究设计，对7683名MS患者的纵向定时25英尺步行(T25-FW)数据进行潜在类别增长分析，以确定T25-FW的轨迹。评估了轨迹分配和个体属性之间的关联。对2591名早期疾病患者进行了重复分析。在普通患者群体中，发现了6条轨迹，从基线的非常轻微的损害到非常高的损害，损害累积率存在变异性。有中度到极高行走障碍的人群与女性、老年和美国黑人、症状持续时间较长、进行性病程和抑郁症状有关。在早期疾病亚组中，识别出8个轨迹，其中包括2个迅速累积损害的亚组。我们确定了MS患者的新亚组将区分T25-FW的长期轨迹。这些结果强调了社会上处于不利地位和经济上被边缘化的多发性硬化症患者最容易受到严重的活动障碍的影响。
Ambulatory impairment is a common and complex manifestation of multiple sclerosis (MS), and longitudinal patterns are not well understood. To characterize longitudinal walking speed trajectories in a general MS patient population and in those with early disease (≤5 years from onset), identify subgroups with similar patterns, and examine associations with individual attributes. Using a retrospective cohort study design, latent class growth analysis was applied to longitudinal timed 25-foot walk (T25-FW) data from 7,683 MS patients, to determine T25-FW trajectories. Associations were evaluated between trajectory assignment and individual attributes. Analyses were repeated for 2,591 patients with early disease. In the general patient population, 6 trajectories were discerned, ranging from very minimal to very high impairment at baseline, with variability in impairment accrual. The clusters with moderate to very high walking impairment were associated with being female, older and Black American, longer symptom duration, progressive course, and depressive symptoms. In the early disease subset, 8 trajectories were discerned, and included 2 subgroups that rapidly accrued impairment. We identified novel subgroups of MS patients will distinct long-term T25-FW trajectories. These results underscore that socially disadvantaged and economically marginalized MS patients are the most vulnerable for severe ambulatory impairment.
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影响因子：
3.4
作者：
Mateen FJ
通讯作者：
Mateen FJ
DOI：
10.1177/13524585211017013
发表时间：
2022-03
期刊：
Multiple sclerosis (Houndmills, Basingstoke, England)
影响因子：
--
作者：
Kalinowski A;Cutter G;Bozinov N;Hinman JA;Hittle M;Motl R;Odden M;Nelson LM
通讯作者：
Nelson LM
影响因子：
6
作者：
Misicka, Elina;Sept, Corriene;Briggs, Farren B. S.
通讯作者：
Briggs, Farren B. S.
DOI：
10.1136/jnnp-2022-328994
发表时间：
2022-07
期刊：
Journal of neurology, neurosurgery, and psychiatry
影响因子：
--
作者：
通讯作者：
--
DOI：
10.2165/11591150-000000000-00000
发表时间：
2011-09-01
影响因子：
3.6
作者：
LaRocca, Nicholas G.
通讯作者：
LaRocca, Nicholas G.