S-100ao protein in serum during acute myocardial infarction.
S-100ao protein in serum during acute myocardial infarction.
复制标题
急性心肌梗死期间血清中的S-100ao蛋白。
DOI：
10.1093/clinchem/36.4.639
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发表时间：
1990
影响因子：
9.3
通讯作者：
E. Takeuchi
中科院分区：
文献类型：
--
作者：
A. Usui;K. Kato;H. Sasa;K. Minaguchi;T. Abe;M. Murase;M. Tanaka;E. Takeuchi
通过酶免疫测定法连续测量了 21 名急性心肌梗死 (AMI) 患者和 6 名心绞痛 (ANP) 患者血清中 S100ao 蛋白（S-100 蛋白的 α α 形式，在心肌中高浓度存在）的浓度。将结果与相同样本中肌酸激酶同工酶 MB (CK-MB) 浓度的测量值进行比较。 100 名健康成人血清中 S100ao 的平均浓度为 0.12 (SD 0.08) 微克/升。 AMI患者入院时S100ao浓度为4.74±5.27微克/升，入院后8小时达到峰值（23.5±27.7微克/升），然后逐渐下降。在发病后一小时内入院的 9 名 AMI 患者中，8 名患者血清中 S100ao 浓度异常高（大于 0.5 微克/L），而只有 4 名患者在入院时血清中 CK-MB 浓度异常高（大于 5 微克/L）。所有 6 名 ANP 患者的血清 S100ao 浓度均保持在正常范围内；然而，其中两人的血清 CK-MB 浓度升高。因此，血清S100ao不仅可用于检测AMI，还可用于区分AMI和ANP。
Concentrations in serum of S100ao protein (alpha alpha form of S-100 protein, which is present at high concentrations in heart muscle) were successively measured by enzyme immunoassay in 21 patients with acute myocardial infarction (AMI) and six with angina pectoris (ANP). Results were compared with measurements of creatine kinase isoenzyme MB (CK-MB) concentrations in the same specimens. Mean S100ao concentrations in sera from 100 healthy adults were 0.12 (SD 0.08) microgram/L. In patients with AMI, S100ao concentrations were 4.74 +/- 5.27 micrograms/L at admission, peaked 8 h after admission (23.5 +/- 27.7 micrograms/L), then decreased gradually. Among nine AMI patients who were admitted within an hour after their attack, eight showed abnormally high concentrations of S100ao in serum (greater than 0.5 microgram/L), whereas only four showed abnormally high CK-MB concentrations (greater than 5 micrograms/L) in sera at the time of admission. Serum S100ao concentrations remained within the normal range in all six patients with ANP; however, serum CK-MB concentrations were increased in two of them. Therefore, serum S100ao is useful not only for detection of AMI but also for differentiating AMI from ANP.