A Fatal Case of a Paint Thinner Ingestion Comparison Between Toxicological and Histological Findings
A Fatal Case of a Paint Thinner Ingestion Comparison Between Toxicological and Histological Findings
复制标题
DOI：
10.1097/paf.0b013e3181c6c11f
复制
发表时间：
2010-06-01
影响因子：
1
通讯作者：
Procaccianti, Paolo
中科院分区：
文献类型：
--
作者：
Argo, Antonina;Bongiorno, David;Procaccianti, Paolo
甲苯和二甲苯是芳香烃，通常用作制造药品、油漆和化学品的工业溶剂。美国职业安全与健康管理局（Occupational Safety and Health Administration）已确定，甲苯含量达到2000 ppm（百万分之2000 ppm）时，即被视为对生命和健康构成危险。几项研究检查了人体吸入和口服甲苯和二甲苯后的吸收情况。被吸收到血液中的挥发性有机化合物分布在整个身体中;特别是，吸收的甲苯和二甲苯在人类和啮齿动物中的分布的特征在于优先吸收在灌注良好的嗜脂组织中，如脑、肝、肺和体脂，以及中枢神经系统。现有的研究表明，二甲苯被迅速吸收，独立于曝光的种类。我们说明了一个致命的情况下，通过摄入清漆稀释溶剂的自我中毒，报告的识别和定量的挥发性有机化合物（甲苯，邻间对二甲苯）从人体生物液体和内脏样本使用固相微萃取-顶空-气相色谱/质谱毒理学分析，并在肝脏，肾脏和肺的组织病理学结果进行评估。
Toluene and xylene are aromatic hydrocarbons commonly used as an industrial solvent for the manufacturing of pharmaceuticals, paints, and chemicals. The Occupational Safety and Health Administration has determined that toluene levels of 2000 parts per million (ppm) are considered dangerous to life and health. Several studies have examined the absorption of toluene and xylene following inhalation and oral ingestion in humans. Volatile organic compounds that are absorbed into the blood are distributed throughout the body; in particular, distribution of absorbed toluene and xylene in humans and rodents is characterized by preferential uptake in well-perfused and lipophil tissues such as the brain, liver, lungs, and body fat and also in central nervous system. The available studies indicate that xylenes are rapidly absorbed independently from the kind of exposition. We illustrate a fatal case of self-poisoning by ingestion of varnishes diluting solvents, reporting the identification and quantification of volatile organic compounds (toluene, o-m-p xylene) from human biologic liquids and viscera samples using the Solid-Phase Microextraction-Headspace-Gas Chromatography/Mass Spectrometry to toxicological analysis, and the histopathological findings evaluated in liver, kidney, and lungs.