Traveling from the hypothalamus to the adipose tissue: The thermogenic pathway.
Traveling from the hypothalamus to the adipose tissue: The thermogenic pathway.
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DOI：
10.1016/j.redox.2017.04.019
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发表时间：
2017-08
期刊：
影响因子：
11.4
通讯作者：
López M
中科院分区：
文献类型：
--
作者：
Contreras C;Nogueiras R;Diéguez C;Rahmouni K;López M
棕色脂肪组织(BAT)是一种特殊的组织，通过线粒体解偶联产生热量，而白色脂肪组织(WAT)负责以甘油三酯的形式储存能量。另一种类型的脂肪已经被描述，米色脂肪组织；这种组织出现在现有的水库中，但具有生热能力，这种现象被称为褐变。一些传递能量状态信息的外周信号在大脑中发挥作用，特别是在下丘脑，以调节蝙蝠的产热和水的褐变。下丘脑不同区域通过交感神经系统(SNS)调节棕色和米色脂肪细胞的产热过程。这篇综述讨论了关于中央控制产热的重要概念和发现，它是从下丘脑开始的一次旅行，通过交感神经到达棕色和米色脂肪来调节生热功能。
Brown adipose tissue (BAT) is a specialized tissue critical for non-shivering thermogenesis producing heat through mitochondrial uncoupling; whereas white adipose tissue (WAT) is responsible of energy storage in the form of triglycerides. Another type of fat has been described, the beige adipose tissue; this tissue emerges in existing WAT depots but with thermogenic ability, a phenomenon known as browning. Several peripheral signals relaying information about energy status act in the brain, particularly the hypothalamus, to regulate thermogenesis in BAT and browning of WAT. Different hypothalamic areas have the capacity to regulate the thermogenic process in brown and beige adipocytes through the sympathetic nervous system (SNS). This review discusses important concepts and discoveries about the central control of thermogenesis as a trip that starts in the hypothalamus, and taking the sympathetic roads to reach brown and beige fat to modulate thermogenic functions.