Amplitudes of auditory P300 in remitted and residual schizophrenics: correlations with clinical features.
Amplitudes of auditory P300 in remitted and residual schizophrenics: correlations with clinical features.
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缓解和残留精神分裂症患者的听觉 P300 振幅：与临床特征的相关性。
DOI：
10.1159/000118953
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发表时间：
1993
影响因子：
3.2
通讯作者：
K. Maurer
中科院分区：
文献类型：
--
作者：
W. Strik;T. Dierks;K. Maurer
本文采用非参照依赖的方法对18例精神分裂症患者和18例年龄、性别相匹配的对照者进行了听觉P300参数的研究。在精神分裂症组中，P300波幅与阴性症状评定量表和简明精神病评定量表评定的精神病理水平呈显著负相关。有关社会功能和适应的临床变量，评估与情感障碍和精神分裂症的时间表，并与DSM-III-R的轴V，与低振幅显着相关。与对照组相比，精神分裂症患者P300电位最大值和最小值的头皮位置有向右移位的趋势。结果表明，低P300振幅与广泛性认知障碍。未来的研究将确定低P300振幅是否对精神分裂症的病程和结局具有预后有效性。
The parameters of auditory P300 were studied with reference-independent methods in a group of 18 remitted and residual schizophrenics, and in 18 age- and sex-matched controls. In the schizophrenic group, significant inverse correlations were found between P300 amplitudes and level of psychopathology assessed with the Scale for Assessment of Negative Symptoms and with the Brief Psychiatric Rating Scale. Clinical variables regarding social functioning and adaptation, assessed with the Schedule for Affective Disorders and Schizophrenia, and with axis V of DSM-III-R, correlated significantly with low amplitudes. The scalp locations of the maxima and minima of the P300 potentials had the tendency to be dislocated to the right in schizophrenics compared with controls. The results indicate low P300 amplitudes to be associated with pervasive cognitive impairment. Future studies will determine whether low P300 amplitudes have prognostic validity for course and outcome of schizophrenic disorders.