The characteristics of sub 10 nm manganese oxide T1 contrast agents of different nanostructured morphologies
The characteristics of sub 10 nm manganese oxide T1 contrast agents of different nanostructured morphologies
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DOI：
10.1016/j.biomaterials.2010.01.087
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发表时间：
2010-05-01
期刊：
影响因子：
14
通讯作者：
Yeh, Chen-Sheng
中科院分区：
文献类型：
--
作者：
Huang, Chih-Chia;Khu, Ngee-Huat;Yeh, Chen-Sheng
人们对开发锰基 T-1 造影剂一直感兴趣。尽管人们在合成锰螯合物方面付出了很多努力，但作为 MRI 造影剂的锰基纳米粒子（特别是氧化锰）的开发正在蓬勃发展。在本报告中，合成了 Mn3O4 的亚 10 nm 纳米球、纳米板和纳米立方体，并根据超导量子干涉装置 (SQUID) 测量在室温下表现出顺磁行为。通过X射线光电子能谱（XPS）检测，表面Mn3+钝化的纳米板具有已报道的氧化锰纳米颗粒中最大的r(1)弛豫率。 Mn3O4纳米板处理的A549肺癌细胞的MR标记分析表明，当Mn离子浓度降至1.3 x 10(-2) mm时，与未处理的细胞相比，T-1加权图像中的MR信号增加至139%。采用暗视野照明显微镜监测内化到细胞中的 Mn3O4 纳米板随时间的变化。 (C) 2010 Elsevier Ltd. 保留所有权利。
There is continuous interest in developing manganese-based T-1 contrast agents. While much effort has been made to synthesize manganese chelates, the development of manganese-based nanoparticle, particularly manganese oxides, as MRI contrast agents is burgeoning. In this report, sub-10-nm nanospheres, nanoplates, and nanocubes of Mn3O4 were synthesized and exhibited paramagnetic behavior at room temperature on the basis of superconducting quantum interference devices (SQUID) measurements. The surface Mn3+ passivated nanoplates examined by x-ray photoelectron spectroscopy (XPS) had the largest r(1) relaxivity of the reported manganese oxide nanoparticles. The MR labeling assays of Mn3O4 nanoplate-treated A549 lung cancer cells showed that MR signals increased to 139% in T-1-weighted images compared with untreated cells when the Mn ion concentration went down to 1.3 x 10(-2) mm. A dark field illumination microscope was employed to monitor Mn3O4 nanoplates internalized into cells as a function of time. (C) 2010 Elsevier Ltd. All rights reserved.