Diabetes preceding Parkinson's disease onset. A case-control study
Diabetes preceding Parkinson's disease onset. A case-control study
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DOI：
10.1016/j.parkreldis.2009.02.013
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发表时间：
2009-11-01
影响因子：
4.1
通讯作者：
Savettieri, Giovanni
中科院分区：
文献类型：
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作者：
D'Amelio, Marco;Ragonese, Paolo;Savettieri, Giovanni
目的：目的：探讨帕金森病（PD）合并糖尿病与PD的关系。方法：随机抽取同一地区的PD患者与无PD患者进行配对。通过结构化问卷调查评估病例和对照组中PD发作前糖尿病的发生率。还收集了有关当前和既往医疗以及其他变量的信息。我们使用单变量和多变量logistic模型计算粗比值比和调整后比值比（OR）。协变量调整包括教育，吸烟习惯，酒精和咖啡consumption.Results：318 PD个体（165名女性，153名男性）和318匹配的对照组被纳入研究。PD患者在访谈时的平均年龄为66.7岁。PD发作时的平均年龄为60.8岁，平均PD持续时间为5.9年。我们发现，在所有按性别、PD发病时年龄、体重指数（BMI）、吸烟习惯、饮酒和咖啡消耗分层的组中，PD和PD发病前的糖尿病之间呈负相关。多变量分析得出了相同的结果后，控制变量（调整OR 0.4，95%CI，0.2-0.8）。结论：我们的研究结果提供了额外的支持糖尿病和PD之间的潜在联系。(C)2009爱思唯尔有限公司保留所有权利。
Objective: To assess the association between diabetes preceding Parkinson's disease (PD) and PD.Methods: PD individuals were matched to PD free individuals randomly selected from people in the same municipality as the cases. Occurrence of diabetes preceding PD onset among cases and controls was assessed through a structured questionnaire. Information regarding current and past medical treatment and other variables was also collected. We used univariate and multivariate logistic models to calculate crude and adjusted odds ratios (OR). Covariates are adjusted for included education, smoking habit, alcohol and coffee consumption.Results: 318 PD individuals (165 women, 153 men) and 318 matched controls were included in the study. PD patients had a mean age at interview of 66.7 years. Mean age at PD onset was 60.8 years and mean PD duration 5.9 years. We found an inverse association between PD and diabetes preceding PD onset in all groups stratified by gender, age at PD onset, body mass index (BMI), smoking habit, alcohol and coffee consumption. Multivariate analysis yielded the same findings after controlling for the variables (adjusted OR 0.4; 95% CI, 0.2-0.8).Conclusions: Our findings provide additional support for a potential link between diabetes and PD. (C) 2009 Elsevier Ltd. All rights reserved.