The impact of induced anxiety on affective response inhibition.
The impact of induced anxiety on affective response inhibition.
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DOI：
10.1098/rsos.170084
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发表时间：
2017-06
影响因子：
3.5
通讯作者：
Robinson OJ
中科院分区：
文献类型：
--
作者：
Aylward J;Valton V;Goer F;Mkrtchian A;Lally N;Peters S;Limbachya T;Robinson OJ
在健康志愿者中研究实验诱导的焦虑的影响可能会增加我们对焦虑障碍的机制的理解。实验诱导的压力（通过不可预测的电击威胁）提高了在持续关注反应任务（SART）中隐瞒反应的准确性，在单独的研究中，提高了对恐惧面孔进行分类的准确性，从而产生了情感偏见。综合这些发现，我们招募了两个公共科学参与事件的参与者（n = 46, n = 55）来探索实验诱导的压力对SART情感版本的影响。我们假设，在受到电击威胁的情况下，我们会看到对情感一致的刺激（即对害怕的“不去”的干扰物）隐瞒反应的准确性提高。诱发性焦虑减慢了反应时间，而在第二个事件中，对可怕刺激的反应更快。然而，我们没有观察到诱导焦虑期间整体抑制的改善，也没有证据表明诱导焦虑和刺激效价对反应准确性有相互作用。事实上，贝叶斯分析提供了反对这一假设的决定性证据。我们认为，情绪刺激的存在可能会使安全条件更具焦虑性，减少条件之间的差异，并消除任何威胁增强的改善。
Studying the effects of experimentally induced anxiety in healthy volunteers may increase our understanding of the mechanisms underpinning anxiety disorders. Experimentally induced stress (via threat of unpredictable shock) improves accuracy at withholding a response on the sustained attention to response task (SART), and in separate studies improves accuracy to classify fearful faces, creating an affective bias. Integrating these findings, participants at two public science engagement events (n = 46, n = 55) were recruited to explore the effects of experimentally induced stress on an affective version of the SART. We hypothesized that we would see an improved accuracy at withholding a response to affectively congruent stimuli (i.e. increased accuracy at withholding a response to fearful ‘no-go’ distractors) under threat of shock. Induced anxiety slowed reaction time, and at the second event quicker responses were made to fearful stimuli. However, we did not observe improved inhibition overall during induced anxiety, and there was no evidence to suggest an interaction between induced anxiety and stimulus valence on response accuracy. Indeed Bayesian analysis provided decisive evidence against this hypothesis. We suggest that the presence of emotional stimuli might make the safe condition more anxiogenic, reducing the differential between conditions and knocking out any threat-potentiated improvement.