ETIOLOGY OF PEPTIC-ULCER - A PROSPECTIVE POPULATION STUDY IN NORWAY
ETIOLOGY OF PEPTIC-ULCER - A PROSPECTIVE POPULATION STUDY IN NORWAY
复制标题
DOI：
10.1136/jech.48.2.156
复制
发表时间：
1994-04-01
影响因子：
6.3
通讯作者：
BURHOL, PG
中科院分区：
文献类型：
--
作者：
JOHNSEN, R;FORDE, OH;BURHOL, PG
研究目的-同时分析几个危险因素对消化性溃疡的影响。设计-队列研究，其中所有新的或事件的消化性溃疡患者在一个定义明确的人口登记了7年的时间。随访从全面的健康调查开始，包括关于饮食、生活方式、心理和社会状况以及健康的问卷调查。相对风险，性别特异性和单独的，胃和十二指肠溃疡的比例风险回归analysis.Setting估计-一项基于人口的调查，在挪威北方特罗姆瑟市进行。参与者----1980年，共有21440名年龄分别为20至54岁和20至49岁的男性和女性被邀请参加。参与者-在1980年，共有21440名男性和女性，年龄分别为20至54岁和20至49岁，应邀参加。共有14667人参加并返回了问卷。主要结果-在随访期间，共有328人首次出现消化性溃疡。年龄、吸烟、一级亲属患消化性溃疡和低教育水平是男女消化性溃疡的共同危险因素。在男性中，频繁的上呼吸道感染会增加胃溃疡的风险，喝大量牛奶会增加十二指肠溃疡的风险。其他饮食变量，包括咖啡和酒精消费，都没有显著增加风险。使用止痛药不是一个危险因素，没有心理指标分析进行任何显着risk.Conclusions -年龄，遗传，吸烟都是重要的危险因素消化性溃疡。与低教育背景相关的风险增加表明，社会压力，包括生活方式和饮食习惯，是消化性溃疡多因素病因学的一部分。消化性溃疡病是一种心身疾病的假设没有得到支持。这项研究并不支持十二指肠溃疡和胃溃疡有不同病因的观点-相反，它显示了风险模式的相似性。
Study objective - To analyse simultaneously the effect of several risk factors for peptic ulcer.Design - Cohort study where all patients with new or incident peptic ulcers in a well defined population were registered for a seven year period. The follow up started with a comprehensive health survey including a questionnaire on diet, lifestyle, psychological and social conditions, and health. Relative risks, both sex specific and separate, for gastric and duodenal ulcers were estimated from proportional hazard regression analysis.Setting - A population based survey conducted in the municipality of Tromso, northern Norway. Participants - In 1980, a total of 21440 men and women, aged 20 to 54 years and 20 to 49 years respectively, were invited to participate. A total of 14667 people attended and returned the questionnaire.Participants - In 1980, a total of 21440 men and women, aged 20 to 54 years and 20 to 49 years respectively, were invited to participate. A total of 14667 people attended and returned the questionnaire. Main results - A total of 328 people had their first peptic ulcer in the follow up period. Age, cigarette smoking, first degree relatives with peptic ulcer, and low educational level were shared risk factors for peptic ulcer in both men and women. In men, frequent upper respiratory infections increased the risk of gastric ulcer and drinking a great deal of milk increased the risk of duodenal ulcer. None of the other dietary variables, including coffee and alcohol consumption, contributed significantly to the risk. Use of analgesics was not a risk factor, and none of the psychological indicators analysed carried any significant risk.Conclusions - Age, inheritance, and cigarette smoking are all important risk factors for peptic ulcer. The increased risk associated with low educational background indicate that social strains, comprising lifestyle and diet habits, are part of the multifactorial aetiology of peptic ulcer. No support was found for the assumption that peptic ulcer disease is a psychosomatic disorder. This study did not support the view that duodenal and gastric ulcers have different aetiologies - rather it showed a similarity in risk patterns.