Higher levels of 25-hydroxyvitamin D are associated with a lower incidence of multiple sclerosis only in women
Higher levels of 25-hydroxyvitamin D are associated with a lower incidence of multiple sclerosis only in women
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DOI：
10.1177/1352458508095920
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发表时间：
2009-01-01
影响因子：
5.8
通讯作者：
Lips, P.
中科院分区：
文献类型：
--
作者：
Kragt, J. J.;van Amerongen, B. M.;Lips, P.
简介 多发性硬化症 (MS) 是一种慢性炎症性疾病，其病因学背景尚未完全了解。 MS 的地理分布十分引人注目，患病率随纬度的增加而增加。因此，维生素 D 缺乏被认为是 MS 可能的致病辅助因素。 材料和方法 为了研究维生素 D 代谢在 MS 中的作用，从 103 名 MS 患者和 110 名健康对照中采集了两次血样（夏季和冬季）。测量了 25-羟基维生素 D (25(OH)D) 和 1,25-二羟基维生素 D (1,25(OH)(2)D) 的血清浓度，并收集了可能影响维生素 D 代谢水平的疾病特征和环境因素的详细信息。 结果 与冬季相比，患者和对照组的平均血清 25(OH)D 和 1,25(OH)(2)D 浓度在夏季显着较高。使用逻辑回归方法，我们发现，在女性中，血清 25(OH)D 水平每增加 10 nmol/L，MS 的几率就会降低 19%（优势比 0.81；95% 置信区间：0.69-0.95），表明较高的 25(OH)D 血清水平具有“保护”作用。此外，同样仅限于女性，扩展残疾状态量表与 25(OH)D 水平之间也存在负相关性 (r = -0.29，P = 0.020)。 结论 我们的数据表明，女性中较高的 25(OH)D 循环水平与较低的 MS 和 MS 相关残疾发生率相关。这可能暗示着风险性别差异的发病机制以及 MS 所涉及的环境因素的性质。多发性硬化症 2009；15：9-15。 http://msj.sagepub.com
Introduction Multiple sclerosis (MS) is a chronic inflammatory disease with an as yet not fully understood etiological background. The geographical distribution of MS is striking with a prevalence that increases with latitude. For this reason, vitamin D deficiency is considered a possible pathogenic co-factor in MS.Materials and methods To study the role of the vitamin D metabolism in MS, blood samples were taken twice (summer and winter) from 103 patients with MS and 110 healthy controls. Serum concentrations of 25-hydroxyvitamin D (25(OH)D) and 1,25-dihydroxyvitamin D (1,25(OH)(2)D) were measured, and detailed information on disease characteristics and environmental factors that might influence the vitamin D metabolite levels was collected.Results Mean serum 25(OH)D and 1,25(OH)(2)D concentrations were significantly higher in summer compared to winter in both patients and controls. Using logistic regression methods, we found that in women for every 10 nmol/L increase of serum 25(OH)D level the odds of MS was reduced by 19% (odds ratio 0.81; 95% confidence interval: 0.69-0.95), suggesting a "protective" effect of higher 25(OH)D serum levels. In addition, also restricted to women, a negative correlation was found between Expanded Disability Status Scale and 25(OH)D levels (r = -0.29, P = 0.020).Conclusions Our data suggest that higher circulating levels of 25(OH)D are associated with a lower incidence of MS and MS-related disability in women. This may imply clues to the pathogenesis of the sex difference in risk and to the nature of the environmental factors involved in MS. Multiple Sclerosis 2009;15:9-15. http://msj.sagepub.com