Intraoperative cytologic diagnosis of sentinel node metastases in breast cancer
Intraoperative cytologic diagnosis of sentinel node metastases in breast cancer
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DOI：
10.1159/000326640
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发表时间：
2003-11-01
期刊：
影响因子：
1.8
通讯作者：
Miyazaki, M
中科院分区：
文献类型：
--
作者：
Nagashima, T;Suzuki, M;Miyazaki, M
目的：为了澄清的有用性，术中调查的前哨淋巴结的乳腺癌，比较结果与检查使用冷冻和永久section.Study设计：材料包括303前哨淋巴结的124例临床淋巴结阴性乳腺癌。从前哨淋巴结的同一切面获得触摸印迹细胞学载玻片和冷冻切片。结果：印片细胞学诊断乳腺癌的敏感性、特异性和准确性分别为70.3%、99.6%和96.0%，冰冻切片诊断乳腺癌的敏感性、特异性和准确性分别为83.8%、100%和98.0%。两种方法联合应用后，乳腺癌前哨淋巴结的检出率分别为89.2%、99.6%、98.3%，而印片细胞学与冰冻切片的符合率为91.9%。结论：印片细胞学与冰冻切片均能有效地评价乳腺癌前哨淋巴结的状态。但应将这两种技术结合起来，以提高诊断的敏感性。
OBJECTIVE: To clarify the usefulness of imprint cytology for intraoperative investigations of sentinel lymph nodes in breast cancer, comparing the results with those of examinations using frozen and permanent sections.STUDY DESIGN: The material consisted of 303 sentinel lymph nodes from 124 cases of clinically node negative breast cancer. Touch imprint cytologic slides and frozen sections were obtained from the same cut surface of the sentinel nodes. Correlations with the final histopathologic results in paraffin sections were evaluated.RESULTS: The sensitivity, specificity and accuracy of imprint cytology were 70.3%, 99.6% and 96.0%, and those of frozen sections were 83.8%, 100%, 98.0%, respectively. The values were improved when the 2 methods were combined (89.2%, 99.6%, 98.3%), though the concordance between imprint cytology and frozen section was 91.9%.CONCLUSION: Both imprint cytology and frozen section are useful for evaluating sentinel lymph node status in breast cancer. However, the 2 techniques should be combined to improve the diagnostic sensitivity.