The chemical synthesis of human milk oligosaccharides: Lacto-N-neotetraose (Galβ1 →4GlcNAcβ1 →3Galβ1 →4Glc)
The chemical synthesis of human milk oligosaccharides: Lacto-N-neotetraose (Galβ1 →4GlcNAcβ1 →3Galβ1 →4Glc)
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DOI：
10.1016/j.carres.2019.107743
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发表时间：
2019-09-01
影响因子：
3.1
通讯作者：
Demchenko, Alexei, V
中科院分区：
文献类型：
--
作者：
Bandara, Mithila D.;Stine, Keith J.;Demchenko, Alexei, V
创新方法的发现为从母乳中获取单个寡糖提供了新的能力，这将有助于加深对其作用的理解，并促进实际应用。利用线性策略和收敛策略完成了N-新四糖(LNnT)的全化学合成。供体和受体的保护和离开基团的组合是成功配对的关键。
The discovery of innovative methods that offer new capabilities for obtaining individual oligosaccharides from human milk will help to improve understanding their roles and boost practical applications. The total chemical synthesis of lacto-N-neotetraose (LNnT) has been completed using both linear and convergent strategies. The donor and acceptor protecting and leaving group combinations were found to be of paramount significance to successful couplings.