Relationships between frontal metabolites and Alzheimer's disease biomarkers in cognitively normal older adults.
Relationships between frontal metabolites and Alzheimer's disease biomarkers in cognitively normal older adults.
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DOI：
10.1016/j.neurobiolaging.2021.09.016
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发表时间：
2022-01
影响因子：
4.2
通讯作者：
Crosson, Bruce
中科院分区：
文献类型：
--
作者：
Hone-Blanchet, Antoine;Bohsali, Anastasia;Krishnamurthy, Lisa C.;Shahid, Salman;Lin, Qixiang;Zhao, Liping;Loring, David;Goldstein, Felicia;John, Samantha E.;Fleischer, Candace C.;Levey, Allan;Lah, James;Qiu, Deqiang;Crosson, Bruce
关键词：
β-淀粉样蛋白(Aβ1-42)和tau的高表达被认为是健康老年人阿尔茨海默病的危险因素。我们研究了年龄和脑脊液中Aβ1-42和tau水平对1)质子磁共振波谱(MRS)测定额叶代谢物和2)认知正常老年人(年龄50-85岁)认知的影响。根据年龄预测额叶γ-氨基丁酸(GABA+)和肌醇/肌酸(mI/TCR)水平。GABA+水平比MI/TCR更能预测认知成绩。此外，我们还发现，通过t-tau水平可以预测n-乙酰天冬氨酸与肌酸的比值(tNAA/TCR)。在认知正常的老年人中，额叶GABA+和mI/TCR水平随年龄增长而下降，而mI/TCR则相反。这些结果表明，大脑代谢物中与年龄和生物标记物相关的变化并不像以前的研究所表明的那样仅位于后部皮质，进一步证明了MRS是研究与病理性衰老和阿尔茨海默病相关的衰老和生物标记物的可行工具。
Elevated expression of β-amyloid (Aβ1-42) and tau are considered risk-factors for Alzheimer’s disease in healthy older adults. We investigated the effect of aging and cerebrospinal fluid levels of Aβ1-42 and tau on 1) frontal metabolites measured with proton magnetic resonance spectroscopy (MRS) and 2) cognition in cognitively normal older adults (n = 144; age range 50-85). Levels of frontal gamma aminobutyric acid (GABA+) and myo-inositol relative to creatine (mI/tCr) were predicted by age. Levels of GABA+ predicted cognitive performance better than mI/tCr. Additionally, we found that frontal levels of n-acetylaspartate relative to creatine (tNAA/tCr) were predicted by levels of t-tau. In cognitively normal older adults, levels of frontal GABA+ and mI/tCr are predicted by aging, with levels of GABA+ decreasing with age and the opposite for mI/tCr. These results suggest that age- and biomarker-related changes in brain metabolites are not only located in the posterior cortex as suggested by previous studies and further demonstrate that MRS is a viable tool in the study of aging and biomarkers associated with pathological aging and Alzheimer’s disease.
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影响因子：
5.7
作者：
Goetz, Margarethe E.;Hanfelt, John J.;Lah, James J.
通讯作者：
Lah, James J.
DOI：
10.1016/0005-2760(89)90265-8
发表时间：
1989-08-08
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
GLANVILLE, NT;BYERS, DM;PALMER, FBSC
通讯作者：
PALMER, FBSC
影响因子：
3.3
作者：
GRUETTER, R
通讯作者：
GRUETTER, R
影响因子：
4.4
作者：
Edden, Richard A. E.;Puts, Nicolaas A. J.;Harris, Ashley D.;Barker, Peter B.;Evans, C. John
通讯作者：
Evans, C. John
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y