A familiar conspecific is more effective than an unfamiliar conspecific for social buffering of conditioned fear responses in male rats
A familiar conspecific is more effective than an unfamiliar conspecific for social buffering of conditioned fear responses in male rats
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DOI：
10.1016/j.bbr.2014.03.043
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发表时间：
2014-07-01
影响因子：
2.7
通讯作者：
Mori, Yuji
中科院分区：
文献类型：
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作者：
Kiyokawa, Yasushi;Honda, Akira;Mori, Yuji
在群居动物中，附属同种的存在可以减轻急性应激反应，这被称为群居缓冲。我们之前在雄性大鼠中报告说，同种刺激的存在缓解了对听觉条件刺激的条件性恐惧反应，并伴随着脚部电击。随后的研究表明，当老鼠在被同种异物气味的盒子里进行测试时，我们可以观察到这种社交缓冲。由于我们之前使用了不熟悉的同种，熟悉同种对社交缓冲强度的影响仍不清楚。在这里，我们通过准备一个熟悉的同种异物来研究这个问题，该同种异物已经与一个受试者在同一个笼子里关了3周。我们让有恐惧条件的受试者在干净的控制箱或事先被陌生或熟悉的同种异物散发气味的箱中接受条件刺激。当受试者在控制箱中进行测试时，他们在室旁核显示了冰冻和Fos的表达。当我们把老鼠放在有同种异物气味的盒子里时，这些反应被抑制了。然而，当盒子被熟悉的同种气味比由陌生的同种气味时，抑制作用更大。杏仁外侧核的FOS表达也以同样的方式受到抑制。这些结果表明，熟悉的同种生物对社会缓冲条件性恐惧反应更有效。(C)2014爱思唯尔B.V.保留所有权利。
In social animals, the presence of an affiliative conspecific alleviates acute stress responses, and this is called social buffering. We previously reported in male rats that the presence of a conspecific mitigates conditioned fear responses to auditory conditioned stimulus paired with foot shocks. Subsequent studies revealed that we could observe this social buffering when rats were tested in a box odorized by a conspecific. Because we previously used an unfamiliar conspecific, the effects of familiarity with a conspecific on the intensity of social buffering remain unclear. Here, we examine this question by preparing a familiar conspecific that had been housed with a subject for 3 weeks in the same cage. We exposed fear-conditioned subjects to a conditioned stimulus in either a clean control box or a box odorized beforehand by either an unfamiliar or a familiar conspecific. When the subjects were tested in the control box, they showed freezing and Fos expression in the paraventricular nucleus. These responses were suppressed when we placed rats in the box odorized by a conspecific. However, the suppression was greater when the box was odorized by a familiar conspecific rather than by an unfamiliar conspecific. Fos expression in the lateral amygdala was also suppressed in the same manner. These results suggest that a familiar conspecific is more effective for social buffering of conditioned fear responses. (C) 2014 Elsevier B.V. All rights reserved.