Hematotoxicity among Chinese workers heavily exposed to benzene
Hematotoxicity among Chinese workers heavily exposed to benzene
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DOI：
10.1002/(sici)1097-0274(199603)29:3
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发表时间：
1996-03-01
影响因子：
3.5
通讯作者：
Hayes, RB
中科院分区：
文献类型：
--
作者：
Rothman, N;Li, GL;Hayes, RB
苯是一种公认的血液毒素。然而，关于其对特定血细胞影响的报道有些不一致，苯代谢物对人类外周血细胞的相对毒性尚未得到评估。我们在一项横断面研究中比较了44名重度接触苯的工人（中位数：百万分之31 [ppm]作为8小时时间加权平均值[TWA]）和44名年龄和性别匹配的未接触苯的对照者的血液学结果。与对照组相比，暴露工人的所有血液学参数（白细胞总数、绝对淋巴细胞计数、血小板、红细胞和红细胞压积）都降低了，但红细胞平均红细胞体积（MCV）在暴露者中较高。在5个采样日（n = 11, 8小时TWA中位数= 7.6 ppm，范围= 1-20 ppm）中未暴露于超过31 ppm苯的工人亚组中，暴露工人（平均[sd] 1.6 [0.4] × 10(3) μ L）和对照组（1.9 [0.4]× 10(3) μ L, p = 0.03）之间只有绝对淋巴细胞计数显著不同。在暴露对象中，仅WBC总数、绝对淋巴细胞计数和MCV与当前苯暴露的各种测量（即个人空气监测、尿中苯代谢物）存在剂量-反应关系。苯代谢物与血液学参数之间的相关性大致相似，尽管对苯二酚与绝对淋巴细胞计数的减少有更强的相关性，儿茶酚与MCV的增加有更强的相关性。外周血玻片的形态学检查显示，只有在暴露最严重的工人中，红细胞（即气孔细胞和靶细胞）异常过多，粒细胞、淋巴细胞或血小板形态未见差异。尽管苯可以影响所有主要的外周血元素，但我们的研究结果支持使用绝对淋巴细胞计数作为苯诱导的血液毒性最敏感的指标。(C) 1995 Wiley-Liss, Inc。
Benzene is a well-established hematotoxin. However, reports of its effects on specific blood cells have been somewhat inconsistent and the relative toxicity of benzene metabolites on peripheral blood cells in humans has not been evaluated. We compared hematologic outcomes in a cross-sectional study of 44 workers heavily exposed to benzene (median: 31 parts permillion [ppm] as an 8-hr time-weighted average [TWA] and 44 age and gender-matched unexposed controls from Shanghai, China. All hematologic parameters (total white blood cells [WBC], absolute lymphocyte count, platelets, red blood cells, and hematocrit) were decreased among exposed workers compared to controls, with the exception of the red blood cell mean corpuscular volume (MCV), which was higher among exposed subjects. In a subgroup of workers who were not exposed to more than 31 ppm benzene on any of 5 sampling days (n = 11, median 8 hr TWA = 7.6 ppm, range = 1-20 ppm), only the absolute lymphocyte count was significantly different between exposed workers (mean [sd] 1.6 [0.4] x 10(3) mu L) and controls (1.9 [0.4] x 10(3) mu L, p = 0.03). Among exposed subjects, a dose-response relationship with various measures of current benzene exposure (i.e., personal air monitoring, benzene metabolites in urine) was present only for the total WBC count, the absolute lymphocyte count, and the MCV. Correlations between benzene metabolites and hematologic parameters were generally similar, although hydroquinone was somewhat more strongly associated with a decrease in the absolute lymphocyte count, and catechol was more strongly associated with an increase in MCV. Morphologic review of peripheral blood slides demonstrated and excess of red blood cell abnormalities (i.e., stomatocytes and target cells) only in the most heavily exposed workers, with no differences in granulocyte, lymphocyte, or platelet morphology noted. Although benzene can affect all the major peripheral blood elements, our results support the use of the absolute lymphocyte count as the most sensitive indicator of benzene-induced hematotoxicity. (C) 1995 Wiley-Liss, Inc.